Inhibition of Macrophage Migration Inhibitory Factor Protects against Inflammation and Matrix Deposition in Kidney Tissues after Injury

<div>Inhibition of MIF abolished AA-induced EMT induction and matrix deposition in TECs. Western blot assay showed that AA increased the expression of MIF, type III collagen, <i>α</i>-SMA, and TGF-<i>β</i>1 and decreased the expression of E-cadherin. However, these changes including EMT induction and matrix deposition were inhibited by ISO-1 treatment.</div>

Mediators of Inflammation

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Figure 6

Figure 6: Inhibition of Macrophage Migration Inhibitory Factor Protects against Inflammation and Matrix Deposition in Kidney Tissues after Injury 