Research Article

Walker 256 Tumor Growth Suppression by Crotoxin Involves Formyl Peptide Receptors and Lipoxin A4

Figure 1

Effect of CTX on edema induced by Walker 256 carcinoma cell inoculation. Tumor cells (1 × 106 in 100 µL) were subcutaneously injected into the plantar region of the right hind paw of the rats. CTX (18 µg per rat in 300 µL) or saline (vehicle control) was s.c. administered daily, during 5 days (first injection on day 1, immediately after tumor cell inoculation). The increase in paw volume was determined in rat hind paws before and at different times after cell inoculation. Edema is expressed as percentage of volume increase in relation to the initial volume of the paw. Each point represents the mean ± SEM of 5 rats. , significantly different from mean values for saline injected animals at fifth day after cell injection.