Diagnostic Accuracy of Five Different Fecal Markers for the Detection of Precancerous and Cancerous Lesions of the Colorectum

Table 3

Sensitivities, specificities, and positive and negative predictive values of the fecal markers.

Parameters	M2-PK	HB	HB/HP	Calprotectin	MMP-9
Sensitivity
Adenoma sized ≥1 cm	60	80	80.0
CRC	94.7	94.7	100.0	77.8	72.2
Adenoma sized ≥1 cm + CRC	76.9	87.2	90.9
Specificity
Adenoma sized ≥1 cm	67.5	72.5	52.9
CRC	67.5	72.5	52.9	70.0	95.0
Adenoma sized ≥1 cm + CRC	67.5	72.5	52.9
PPV (%)
Adenoma sized ≥1 cm	80	59.2	42.9
CRC	85.7	62	52.9	53.8	86.6
Adenoma sized ≥1 cm + CRC	69.7	75.5	65.2
NPV (%)
Adenoma sized ≥1 cm	77.1	96.6	85.7
CRC	96.4	96.6	100.0	87.5	88.3
Adenoma sized ≥1 cm + CRC	75	85.3	85.7