Review Article

Metabolism Is Central to Tolerogenic Dendritic Cell Function

Table 1

Dendritic cell therapeutics.

ConditionOrganismAdjuvantMetabolic modulatorImmune responseReferences

PsoriasisHuman1,25(OH)2D3YesIncreased CD4+CD25+ suppressor T cells[13]

Skin transplantMouse1,25(OH)2D3YesIncreased CD25+Foxp3+ Tregs [14]

Allograft rejectionMouseDexamethasoneYes Increased ratio IL-10/IL-12[15]

ColitisMouse 1,25(OH)2D3 & dexamethasoneYesLower CD4+CD25 T cell response[16]

Heart graftMouseRapamycinYesInhibiting T cell IL-2 & IFN-γ production[17]

Heart graftMouseRapamycinYesStimulating CD4+CD25+Foxp3+ Treg[18]

Type-1 diabetesHumanAntisense oligonucleotides
targeting CD40, CD80, and CD86
NoStimulating B220+ CD11c  B-cells[19]

Rheumatoid ArthritisHumanBAY 11-7082NoHigher ratio Treg/effector T cells[20]