Table of Contents Author Guidelines Submit a Manuscript
Mediators of Inflammation
Volume 2016 (2016), Article ID 2748367, 14 pages
http://dx.doi.org/10.1155/2016/2748367
Research Article

Shikonin Attenuates Concanavalin A-Induced Acute Liver Injury in Mice via Inhibition of the JNK Pathway

1Department of Gastroenterology, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai 200072, China
2The First Clinical Medical College, Nanjing Medical University, Nanjing 210029, China
3The First Affiliated Hospital of Soochow University, Suzhou 215006, China

Received 29 December 2015; Accepted 21 March 2016

Academic Editor: Anshu Agrawal

Copyright © 2016 Tong Liu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. M. A. Heneghan, A. D. Yeoman, S. Verma, A. D. Smith, and M. S. Longhi, “Autoimmune hepatitis,” The Lancet, vol. 382, no. 9902, pp. 1433–1444, 2013. View at Publisher · View at Google Scholar · View at Scopus
  2. Q. Wang, F. Yang, Q. Miao, E. L. Krawitt, M. E. Gershwin, and X. Ma, “The clinical phenotypes of autoimmune hepatitis: a comprehensive review,” Journal of Autoimmunity, vol. 66, pp. 98–107, 2016. View at Publisher · View at Google Scholar
  3. G. Tiegs, J. Hentschel, and A. Wendel, “A T cell-dependent experimental liver injury in mice inducible by concanavalin A,” The Journal of Clinical Investigation, vol. 90, no. 1, pp. 196–203, 1992. View at Publisher · View at Google Scholar · View at Scopus
  4. A. Carambia and J. Herkel, “CD4 T cells in hepatic immune tolerance,” Journal of Autoimmunity, vol. 34, no. 1, pp. 23–28, 2010. View at Publisher · View at Google Scholar · View at Scopus
  5. Y. Kaneko, M. Harada, T. Kawano et al., “Augmentation of Vα14 NKT cell-mediated cytotoxicity by interleukin 4 in an autocrine mechanism resulting in the development of concanavalin A-induced hepatitis,” The Journal of Experimental Medicine, vol. 191, no. 1, pp. 105–114, 2000. View at Publisher · View at Google Scholar · View at Scopus
  6. D. S. Pisetsky, “The translocation of nuclear molecules during inflammation and cell death,” Antioxidants and Redox Signaling, vol. 20, no. 7, pp. 1117–1125, 2014. View at Publisher · View at Google Scholar · View at Scopus
  7. G. Tiegs, “Cellular and cytokine-mediated mechanisms of inflammation and its modulation in immune-mediated liver injury,” Zeitschrift fur Gastroenterologie, vol. 45, no. 1, pp. 63–70, 2007. View at Publisher · View at Google Scholar · View at Scopus
  8. S. Kusters, F. Gantner, G. Kunstle, and G. Tiegs, “Interferon gamma plays a critical role in T cell-dependent liver injury in mice initiated by concanavalin A,” Gastroenterology, vol. 111, no. 2, pp. 462–471, 1996. View at Publisher · View at Google Scholar · View at Scopus
  9. C. Trautwein, T. Rakemann, D. A. Brenner et al., “Concanavalin A-induced liver cell damage: activation of intracellular pathways triggered by tumor necrosis factor in mice,” Gastroenterology, vol. 114, no. 5, pp. 1035–1045, 1998. View at Publisher · View at Google Scholar · View at Scopus
  10. H. X. Wang, M. Liu, S.-Y. Weng et al., “Immune mechanisms of Concanavalin A model of autoimmune hepatitis,” World Journal of Gastroenterology, vol. 18, no. 2, pp. 119–125, 2012. View at Publisher · View at Google Scholar
  11. A. Weber, P. Wasiliew, and M. Kracht, “Interleukin-1β (IL-1β) processing pathway,” Science Signaling, vol. 3, no. 105, article cm2, 2010. View at Publisher · View at Google Scholar · View at Scopus
  12. N. Kamo, B. Ke, A. A. Ghaffari et al., “ASC/caspase-1/IL-1β signaling triggers inflammatory responses by promoting HMGB1 induction in liver ischemia/reperfusion injury,” Hepatology, vol. 58, no. 1, pp. 351–362, 2013. View at Publisher · View at Google Scholar · View at Scopus
  13. T. Torisu, M. Nakaya, S. Watanabe et al., “Suppressor of cytokine signaling 1 protects mice against concanavalin A-induced hepatitis by inhibiting apoptosis,” Hepatology, vol. 47, no. 5, pp. 1644–1654, 2008. View at Publisher · View at Google Scholar · View at Scopus
  14. H.-M. Ni, X. Chen, W.-X. Ding, M. Schuchmann, and X.-M. Yin, “Differential roles of JNK in ConA/GalN and ConA-induced liver injury in mice,” The American Journal of Pathology, vol. 173, no. 4, pp. 962–972, 2008. View at Publisher · View at Google Scholar · View at Scopus
  15. J. Li, Y. Xia, T. Liu et al., “Protective effects of astaxanthin on conainduced autoimmune hepatitis by the JNK/p-JNK pathway-mediated inhibition of autophagy and apoptosis,” PLoS ONE, vol. 10, no. 3, Article ID e0120440, 2015. View at Publisher · View at Google Scholar · View at Scopus
  16. A. González-Rodríguez, B. Reibert, T. Amann, R. Constien, C. M. Rondinone, and A. M. Valverde, “In vivo siRNA delivery of Keap1 modulates death and survival signaling pathways and attenuates concanavalin-A-induced acute liver injury in mice,” DMM Disease Models and Mechanisms, vol. 7, no. 9, pp. 1093–1100, 2014. View at Publisher · View at Google Scholar · View at Scopus
  17. A. R. M. R. Amin, V. S. Thakur, K. Gupta et al., “Restoration of p53 functions protects cells from concanavalin A-induced apoptosis,” Molecular Cancer Therapeutics, vol. 9, no. 2, pp. 471–479, 2010. View at Publisher · View at Google Scholar · View at Scopus
  18. T. P. Ashford and K. R. Porter, “Cytoplasmic components in hepatic cell lysosomes,” The Journal of Cell Biology, vol. 12, pp. 198–202, 1962. View at Publisher · View at Google Scholar · View at Scopus
  19. S. T. Shibutani, T. Saitoh, H. Nowag, C. Münz, and T. Yoshimori, “Autophagy and autophagy-related proteins in the immune system,” Nature Immunology, vol. 16, no. 10, pp. 1014–1024, 2015. View at Publisher · View at Google Scholar · View at Scopus
  20. P. Cheng, K. Chen, Y. Xia et al., “Hydrogen sulfide, a potential novel drug, attenuates concanavalin A-induced hepatitis,” Drug Design, Development and Therapy, vol. 8, pp. 1277–1286, 2014. View at Publisher · View at Google Scholar · View at Scopus
  21. R. Wang, R. Yin, W. Zhou, D. Xu, and S. Li, “Shikonin and its derivatives: a patent review,” Expert Opinion on Therapeutic Patents, vol. 22, no. 9, pp. 977–997, 2012. View at Publisher · View at Google Scholar · View at Scopus
  22. C.-C. Lee, C.-N. Wang, Y.-T. Lai et al., “Shikonin inhibits maturation of bone marrow-derived dendritic cells and suppresses allergic airway inflammation in a murine model of asthma,” British Journal of Pharmacology, vol. 161, no. 7, pp. 1496–1511, 2010. View at Publisher · View at Google Scholar · View at Scopus
  23. I. Andújar, M. C. Recio, T. Bacelli, R. M. Giner, and J. L. Ríos, “Shikonin reduces oedema induced by phorbol ester by interfering with IκBα degradation thus inhibiting translocation of NF-κB to the nucleus,” British Journal of Pharmacology, vol. 160, no. 2, pp. 376–388, 2010. View at Publisher · View at Google Scholar · View at Scopus
  24. J. Xiong, J. Ni, G. Hu et al., “Shikonin ameliorates cerulein-induced acute pancreatitis in mice,” Journal of Ethnopharmacology, vol. 145, no. 2, pp. 573–580, 2013. View at Publisher · View at Google Scholar · View at Scopus
  25. C. Wang, Y. Xia, Y. Zheng et al., “Protective effects of N-acetylcysteine in concanavalin a-induced hepatitis in mice,” Mediators of Inflammation, vol. 2015, Article ID 189785, 17 pages, 2015. View at Publisher · View at Google Scholar · View at Scopus
  26. H. X. Wang, M. Liu, S.-Y. Weng et al., “Immune mechanisms of Concanavalin A model of autoimmune hepatitis,” World Journal of Gastroenterology, vol. 18, no. 2, pp. 119–125, 2012. View at Publisher · View at Google Scholar
  27. K. Cui, G. Yan, C. Xu et al., “Invariant NKT cells promote alcohol-induced steatohepatitis through interleukin-1β in mice,” Journal of Hepatology, vol. 62, no. 6, pp. 1311–1318, 2015. View at Publisher · View at Google Scholar · View at Scopus
  28. S.-C. Chiu, S.-W. Tsao, P.-I. Hwang, S. Vanisree, Y.-A. Chen, and N.-S. Yang, “Differential functional genomic effects of anti-inflammatory phytocompounds on immune signaling,” BMC Genomics, vol. 11, article 513, 2010. View at Publisher · View at Google Scholar · View at Scopus
  29. M. Ferdaoussi, S. Abdelli, J.-Y. Yang et al., “Exendin-4 protects β-cells from interleukin-1β-induced apoptosis by interfering with the c-Jun NH2-terminal kinase pathway,” Diabetes, vol. 57, no. 5, pp. 1205–1215, 2008. View at Publisher · View at Google Scholar · View at Scopus
  30. S. H. Kim, C. J. Smith, and L. J. Van Eldik, “Importance of MAPK pathways for microglial pro-inflammatory cytokine IL-1β production,” Neurobiology of Aging, vol. 25, no. 4, pp. 431–439, 2004. View at Publisher · View at Google Scholar · View at Scopus
  31. S. Huang, M. Konieczkowski, J. R. Schelling, and J. R. Sedor, “Interleukin-1 stimulates Jun N-terminal/stress-activated protein kinase by an arachidonate-dependent mechanism in mesangial cells,” Kidney International, vol. 55, no. 5, pp. 1740–1749, 1999. View at Publisher · View at Google Scholar · View at Scopus
  32. L. R. Chaudhary and L. V. Avioli, “Activation of c-Jun NH2-terminal kinases by interleukin-1 beta in normal human osteoblastic and rat UMR-106 cells,” Journal of Cellular Biochemistry, vol. 69, no. 1, pp. 87–93, 1998. View at Publisher · View at Google Scholar · View at Scopus
  33. M. A. Nikulina, N. Sandhu, Z. Shamim et al., “The JNK binding domain of islet-brain 1 inhibits IL-1 induced JNK activity and apoptosis but not the transcription of key proapoptotic or protective genes in insulin-secreting cell lines,” Cytokine, vol. 24, no. 1-2, pp. 13–24, 2003. View at Publisher · View at Google Scholar · View at Scopus
  34. J. H. Lee, J. H. Won, J. M. Choi et al., “Protective effect of ellagic acid on concanavalin A-induced hepatitis via toll-like receptor and mitogen-activated protein kinase/nuclear factor κB signaling pathways,” Journal of Agricultural and Food Chemistry, vol. 62, no. 41, pp. 10110–10117, 2014. View at Publisher · View at Google Scholar · View at Scopus
  35. S. A. Abdel, M. Atia, A. S. Alshehri, A. Sobota, and K. Kwiatkowska, “Ceramide generation during curcumin-induced apoptosis is controlled by crosstalk among Bcl-2, Bcl-xL, caspases and glutathione,” Cellular Signalling, vol. 27, no. 11, pp. 2220–2230, 2015. View at Publisher · View at Google Scholar
  36. K. Yamamoto, H. Ichijo, and S. J. Korsmeyer, “BCL-2 is phosphorylated and inactivated by an ASK1/Jun N-terminal protein kinase pathway normally activated at G2/M,” Molecular and Cellular Biology, vol. 19, no. 12, pp. 8469–8478, 1999. View at Publisher · View at Google Scholar · View at Scopus
  37. S. Mukhopadhyay, P. K. Panda, N. Sinha, D. N. Das, and S. K. Bhutia, “Autophagy and apoptosis: where do they meet?” Apoptosis, vol. 19, no. 4, pp. 555–566, 2014. View at Publisher · View at Google Scholar · View at Scopus