SOCS1 Mimetic Peptide Suppresses Chronic Intraocular Inflammatory Disease (Uveitis)

Figure 4

SOCS1-KIR inhibited expression of proinflammatory cytokines and chemokines during EAU. We induced EAU in rats by active immunization with R16 peptide and the rats were treated with SOCS1-KIR or scrambled peptide (control). (a) Inflammatory cells present in the retina 12 days after disease induction were analyzed by flow cytometry. Plots were gated on CD4⁺ T cells and numbers in quadrants indicate percentage of CD4⁺ T cells expressing IL-17 or IFN-γ. (b, c) qRT-PCR analysis of genes coding for inflammatory cytokines and chemokines in the retinae. Results represent at least three independent experiments. < 0.05, < 0.005, < 0.001.

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