SOCS1 Mimetic Peptide Suppresses Chronic Intraocular Inflammatory Disease (Uveitis)

Figure 6

SOCS1-KIR mitigated EAU pathology by protecting resident retinal cells from apoptosis retinal photoreceptor cells (a), RPE cells (b), or Muller cells (c) were cultured in medium containing the proapoptotic reagent, staurosporine (2 µM), IL-17 (50 ng/mL), SOCS1-KIR, or the scrambled peptide. We determined the percentage of the cells undergoing apoptosis or necrosis by the Annexin-V staining assay. (d, e) The photoreceptor cells were also analyzed for the expression of proapoptotic genes by qPCR. Results represent at least three independent experiments. < 0.05, < 0.005, < 0.001, and < 0.0001 (Student’s -test (two-tailed)).

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