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Mediators of Inflammation
Volume 2016, Article ID 2939658, 11 pages
http://dx.doi.org/10.1155/2016/2939658
Research Article

Doxycycline Inhibits IL-17-Stimulated MMP-9 Expression by Downregulating ERK1/2 Activation: Implications in Myogenic Differentiation

Laboratory for Experimental Hematology and Stem Cells, Institute for Medical Research, University of Belgrade, Dr. Subotića 4, 11129 Belgrade, Serbia

Received 18 August 2016; Accepted 12 October 2016

Academic Editor: Helen C. Steel

Copyright © 2016 Hristina Obradović et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Supplementary Figure:

(A) MMP-2 activity in C2C12 cells treated with increasing concentrations of IL-17 determined by zymography.

(B) Myotube formation in C2C12 cells grown in GM and MDM with or without IL-17 (50 ng/ml).

(C) MMP-2 activity in C2C12 cells treated with increasing concentrations of Doxy determined by zymography.

Supplementary table: primer sequences and PCR settings.

  1. Supplementary Material