Regulatory T Cell Induced by Poria cocos Bark Exert Therapeutic Effects in Murine Models of Atopic Dermatitis and Food Allergy

Figure 2

PCB extract alleviates the symptoms of DNCB/HDM-induced-atopic dermatitis. (a) Typical photographs of ear lesions developed by the treatments of DNCB and HDM on day 62. (b) Ear thickness was measured using digital thickness gauge on next day after HDM treatment from first challenge to sixth. (c) Ear lesions isolated from mice were fixed with 10% formalin solution and embedded in paraffin. To evaluate epidermal thickness and infiltrated inflammatory cells, H&E staining was performed and observed using a microscope at 100x and 200x magnification. (d) Clinical score was determined by criteria such as erythema/edema, scaling/dryness, and excoriation/hemorrhage to evaluate degree of severity in each ear lesion on day 62. Data are presented as the mean ± standard deviation (SD) of triplicate determinations and were analyzed using unpaired -test. , , and versus sham group.

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