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Mediators of Inflammation
Volume 2016 (2016), Article ID 3476240, 8 pages
Review Article

Celecoxib Adjunctive Treatment to Antipsychotics in Schizophrenia: A Review of Randomized Clinical Add-On Trials

1Department of Neurosciences Clinical Imaging, Chair of Psychiatry, “G. d’Annunzio” University, 65100 Chieti, Italy
2Polyedra Research Group, 64100 Teramo, Italy
3NHS, Department of Mental Health, Psychiatric Service of Diagnosis and Treatment, Hospital “G. Mazzini”, ASL 4, 64100 Teramo, Italy
4Villa S. Giuseppe Hospital, Hermanas Hospitalarias, 63100 Ascoli Piceno, Italy
5School of Life and Medical Sciences, University of Hertfordshire, Hatfield AL10 9AB, UK
6New York State Psychiatric Institute, Columbia University, New York, NY 10027, USA

Received 31 January 2016; Revised 23 June 2016; Accepted 27 June 2016

Academic Editor: Vera L. Petricevich

Copyright © 2016 Stefano Marini et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Schizophrenia is a severe, chronic and debilitating mental disorder. Past literature has reported various hypotheses about the psychopathology of schizophrenia. Recently, a growing literature has been trying to explain the role of inflammation in the etiopathogenesis of schizophrenia. In the past, numerous immune modulation and anti-inflammatory treatment options have been proposed for schizophrenia, but sometimes the results were inconsistent. Electronic search was carried out in November 2015. PubMed and Scopus databases have been used to find studies to introduce in this review. Only randomized-placebo-controlled add-on trials were taken into account. In this way, six articles were obtained for the discussion. Celecoxib showed beneficial effects mostly in early stages of schizophrenia. In chronic schizophrenia, the data are controversial, possibly in part for methodological reasons.