Interplay between Cellular and Molecular Inflammatory Mediators in Lung Cancer

Figure 3

Target CD47. Macrophages maintain tissue homeostasis through phagocytosis of apoptotic cells. Interaction with other cell types can increase or inhibit their activity. Adiponectin via calreticulin leads to the uptake of early apoptotic cells by macrophages. However, as an immune evasion mechanism, tumor cells can deregulate the expression of CD47 and thereby inhibit phagocytic activity. Currently, the administration of anti-CD47 antibody activates phagocytosis by blocking interaction SIRP-α/CD47 and inhibits the migration of neutrophils to the tumor site inhibiting their growth.