Circulating Memory T Follicular Helper Cells in Patients with Neuromyelitis Optica/Neuromyelitis Optica Spectrum Disorders

Figure 7

Changes in the numbers of different subsets of circulating memory Tfh cells and plasma IL-21 levels in NMO/NMOSD patients. Among 12 patients with posttreatment follow-up, six patients achieved partial remission (PR) and six patients showed nonremission (NR). The numbers of different subsets of circulating memory Tfh cells and the levels of plasma IL-21 were compared in patients with PR before and after treatment or patients with NR before and after treatment. ((a)-(b)) The numbers of CCR7⁻ICOS⁺, CCR7⁺ICOS⁺ memory Tfh cells in CD4⁺ T cells in patients with PR before and after treatment. (c) The levels of plasma IL-21 in patients with PR before and after treatment. ((d)-(e)) The numbers of CCR7⁻ICOS⁺, CCR7⁺ICOS⁺ memory Tfh cells among CD4⁺ T cells in patients with NR before and after treatment. (f) The levels of plasma IL-21 in patients with NR before and after treatment.

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