The Expression of T Cell FOXP3 and T-Bet Is Upregulated in Severe but Not Euthyroid Hashimoto’s Thyroiditis

Table 2

Descriptive analysis of clinical and biochemical characteristics of patients and healthy controls.

⁢	HYPO HT	SUBST HT	EU HT	CTRL
Subjects	10	10	12	11
Age
Gender (F/M)	8/2	9/1	12/0	10/1
FT4 (pmol/L)
FT3 (pmol/L)
TSH (mIU/L)	10.35 (5.25–13.1)	2.59 (0.9–3.0)	3.11 (1.6–4.3)	1.63 (1.0–2.4)
TPOAb (kIU/mL)	155 (61–2217)	246 (77–969)	677 (267–1112)	neg

Data are presented as mean ± SD or median with interquartile range (25th–75th percentile) according to the distribution. The study included 11 healthy controls (CTRL) and 32 HT patients classified as hypothyroid (HYPO HT), rendered euthyroid by thyroxine (L-T4) replacement therapy (SUBST HT), and spontaneously euthyroid (EU HT).
F: female and M: male. The value represents different groups compared with hypothyroid HT patients.
= 0.00006; = 0.01; = 0.1 × 10⁻⁵; = 0.1 × 10 (Kruskal-Wallis test and Bonferroni-Dunn’s post hoc comparison).
FT4: free thyroxine (normal range: 10–22 pmol/L); FT3: free triiodothyronine (1.9–5.7 pmol/L); TSH: thyroid stimulating hormone (normal range: 0.46–4.7 mIU/L).