Review Article

The Potential Role of 8-Oxoguanine DNA Glycosylase-Driven DNA Base Excision Repair in Exercise-Induced Asthma

Figure 3

OGG1-BER induced gene expression associated with AHR. Mouse lungs received a single challenge (SC) or multiple challenges (MC) of 8-oxoG and were processed as previously described above. (a) Hierarchically clustered heat map was generated using GENE-E online software (Broad Institute, http://www.broadinstitute.org/) considering transcript levels (fold-change). Red represents upregulation and blue represents downregulation. (b) Enrichment network of the known and predicted interactions among the set of genes associated to airway hyperresponsiveness and OGG1. Peripheral nodes represent genes with a direct interaction with OGG1. The modified network was generated with GeneMania online database (http://www.genemania.org/).
(a)
(b)