Review Article

The Potential Role of 8-Oxoguanine DNA Glycosylase-Driven DNA Base Excision Repair in Exercise-Induced Asthma

Table 2

OGG1-BER induced expression of genes associated to AHR.

SymbolNameGenBank/RefSeq IDSC (fold)MC (fold)

Cxcl2Chemokine (C-X-C motif) ligand 2NM_009140192.9548.55
Bdkrb2Bradykinin receptor, beta 2NM_009747−1.3545.16
Il10Interleukin 10NM_0105485.8433.51
Tlr9Toll-like receptor 9NM_031178−1.5425.97
Arg1Arginase, liverNM_007482−5.0017.71
Cxcl1Chemokine (C-X-C motif) ligand 1NM_00817654.4515.94
Esr1Estrogen receptor 1 (alpha)NM_007956−5.1915.56
AlbAlbuminNM_009654−1.7415.28
Chrm3Cholinergic receptor, muscarinic 3, cardiacNM_0332691.669.99
Flt1Fms-like tyrosine kinase 1NM_010228−1.139.06
Chrm2Cholinergic receptor, muscarinic 2, cardiacNM_203491−1.798.73
VipVasoactive intestinal polypeptideNM_011702−2.107.26
TnfTumor necrosis factorNM_01369316.657.13
Col4a3Collagen, type IV, alpha 3NM_0077341.156.74
Tac1Tachykinin 1NM_009311−4.286.70
Mylk3Myosin light chain kinase 3NM_175441−4.086.35
Ppp1r12aProtein phosphatase 1, regulatory (inhib) subunit 12ANM_027892−1.086.06
Ctla4Cytotoxic T-lymphocyte-associated protein 4NM_0098437.085.82
Madcam1Mucosal vascular addressin cell adhesion molecule 1NM_013591−1.635.66
Il1aInterleukin 1 alphaNM_0105544.175.55
AgmatAgmatine ureohydrolase (agmatinase)NM_001081408−4.285.03
Il1RnInterleukin 1 receptor antagonistNM_0311671.924.10
Il2RbInterleukin 2 receptor, beta chainNM_0083681.314.04
Il9RInterleukin 9 receptorNM_0083741.083.96
Edn1Endothelin 1NM_0101043.103.81
Prg2Proteoglycan 2, bone marrowNM_0089202.213.72
MmeMembrane metallo-endopeptidaseNM_008604−1.073.66
CtsgCathepsin GNM_007800−1.143.35
ItkIL2 inducible T cell kinaseNM_0105831.383.34
Pik3r1PI3K, regulatory subunit, polypeptide 1 (p85 alpha)NM_001024955−1.183.24
MpoMyeloperoxidaseNM_0108241.363.24
NgfrNerve growth factor receptor NM_033217−1.883.20
Slc7a1Solute carrier family 7, member 1NM_007513−1.283.19
Pde4dPhosphodiesterase 4D, cAMP specificNM_0110561.083.18
Pde4bPhosphodiesterase 4B, cAMP specificNM_0198401.393.17
EgfrEpidermal growth factor receptorNM_007912−1.163.05
Abl1C-abl oncogene 1, non-receptor tyrosine kinaseNM_0011127031.113.01
Etv6Ets variant 6NM_007961−1.052.98
Tacr2Tachykinin receptor 2NM_009314−1.072.93
Ccl11Chemokine (C-C motif) ligand 11NM_011330−1.712.93
Ttf2Transcription termination factor, RNA polymerase IINM_0010130261.062.92
Il6Interleukin 6NM_03116810.442.75
Pde3bPhosphodiesterase 3B, cGMP-inhibitedNM_011055−1.792.68
Pcdh1Protocadherin 1NM_029357−1.122.66
JunJun proto-oncogeneNM_0105911.382.55
Nqo1NAD(P)H dehydrogenase, quinone 1NM_008706−2.582.54
Il1bInterleukin 1 betaNM_0083614.152.52
CckCholecystokininNM_031161−1.432.51
F2rl1Coagulation factor II (thrombin) receptor-like 1NM_0079741.092.51
MbpMyelin basic proteinNM_010777−1.402.48
Itga4Integrin alpha 4NM_0105761.262.46
F2rCoagulation factor II (thrombin) receptorNM_0101691.462.39
SelpSelectin, plateletNM_011347−1.312.39
Il2raInterleukin 2 receptor, alpha chainNM_0083671.062.34
Agtr1aAngiotensin II receptor, type 1aNM_1773221.722.33
Fgfr1Fibroblast growth factor receptor 1NM_0102061.022.32
MylkMyosin, light polypeptide kinaseNM_1393001.242.30
Klf15Kruppel-like factor 15NM_0231841.412.30
Ltb4r2Leukotriene B4 receptor 2NM_020490−7.372.15
Hrh1Histamine receptor H1NM_008285−2.852.15
Il5Interleukin 5NM_010558−1.872.14
Icam1Intercellular adhesion molecule 1NM_0104931.302.12
Irak3Interleukin-1 receptor-associated kinase 3NM_028679−1.192.12
CftrCystic fibrosis transmembrane conductance regulatorNM_0210501.092.11
ElaneElastase, neutrophil expressedNM_015779−1.432.09
Hspd1Heat shock protein 1 (chaperonin)NM_010477−2.072.06

SC, single 8-oxoG challenge; MC, multiple 8-oxoG challenge; PI3K, phosphatidylinositol 3-kinase; NAD(P)H, dihydronicotinamide-adenine dinucleotide phosphate. The table shows the top ranked genes (MC, 60 min) by expression level (≥2-fold).