TY - JOUR A2 - Kleinjan, Alex AU - Abdel Hadi, Loubna AU - Di Vito, Clara AU - Riboni, Laura PY - 2016 DA - 2016/01/05 TI - Fostering Inflammatory Bowel Disease: Sphingolipid Strategies to Join Forces SP - 3827684 VL - 2016 AB - Complex sphingolipids are essential structural components of intestinal membranes, providing protection and integrity to the intestinal mucosa and regulating intestinal absorption processes. The role of sphingolipid signaling has been established in numerous cellular events, including intestinal cell survival, growth, differentiation, and apoptosis. A significant body of knowledge demonstrates that intestinal sphingolipids play a crucial role, as such and through their signaling pathways, in immunity and inflammatory disorders. In this review, we report on and discuss the current knowledge on the metabolism, signaling, and functional implications of sphingolipids in inflammatory bowel disease (IBD), focusing on the different aspects of sphingolipid actions on inflammatory responses and on the potential of sphingolipid-targeted molecules as anti-IBD therapeutic agents. SN - 0962-9351 UR - https://doi.org/10.1155/2016/3827684 DO - 10.1155/2016/3827684 JF - Mediators of Inflammation PB - Hindawi Publishing Corporation KW - ER -