Anti-Inflammatory Effects of TRAF-Interacting Protein in Rheumatoid Arthritis Fibroblast-Like Synoviocytes

<div>TRIP interacted with TAK1 and promoted TAK1 degradation in RA-FLS. (a) Extracts of RA-FLS stimulated with TNF<i>α</i> (100 ng/mL) for various times were subjected to immunoprecipitation with anti-TRIP or control anti-IgG and immunoblot analysis with individual antibodies. Mg132, proteasome inhibitor. WCL, whole cell lysates (b) Western blot analysis of the expression of TAK1 in RA-FLS cells stably expressed control or TRIP (wild type) or TRIPCA (E3 ligase activity mutation) plasmid stimulated with TNF<i>α</i> (100 ng/mL) for 120 min.</div>

Mediators of Inflammation

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Figure 5

Figure 5: Anti-Inflammatory Effects of TRAF-Interacting Protein in Rheumatoid Arthritis Fibroblast-Like Synoviocytes 