New Role of Adult Lung c-kit+ Cells in a Mouse Model of Airway Hyperresponsiveness
c-kit+ cells positively interfere with the remodeling of asthmatic airways. (a–c) Proliferating (Ki67, green, arrows) epithelial cells (pan-cytokeratin, CK, red) in vehicle- (a) and c-kit+ cell-treated (b) animals. (c) The fraction of Ki67+ epithelial cells. (d-e) Cycling (Ki67, green, arrows) SMCs (α-SMA, red) in the airway wall of vehicle- (d) and c-kit+ cell-treated (e) mice. (f) The fraction of Ki67+ SMCs. (g-h) Mucin-positive goblet cells (green, arrows) in epithelium of vehicle- (g) and c-kit+ cell-treated (h) asthmatic mice. (i) The percentage of epithelial cells expressing mucin. Data in control, OVA, and OVA+cCs mice are the mean ± SD. Scale bars, (a, b, d, e) 20 μm and (g, h) 10 μm. versus control; versus OVA. SMCs: smooth muscle cells; α-SMA: α-smooth muscle actin.
Article of the Year Award: Outstanding research contributions of 2020, as selected by our Chief Editors. Read the winning articles.