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Mediators of Inflammation
Volume 2016, Article ID 4083735, 8 pages
http://dx.doi.org/10.1155/2016/4083735
Review Article

The Role of the IL-20 Subfamily in Glaucoma

Casey Eye Institute, Oregon Health & Science University, 3181 S.W. Sam Jackson Park Road, Portland, OR 97239, USA

Received 20 August 2015; Revised 4 December 2015; Accepted 10 December 2015

Academic Editor: Claudia Cocco

Copyright © 2016 Mary K. Wirtz and Kate E. Keller. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. W. Streilein, “Ocular immune privilege: therapeutic opportunities from an experiment of nature,” Nature Reviews Immunology, vol. 3, no. 11, pp. 879–889, 2003. View at Publisher · View at Google Scholar · View at Scopus
  2. M. Mochizuki, S. Sugita, and K. Kamoi, “Immunological homeostasis of the eye,” Progress in Retinal and Eye Research, vol. 33, no. 1, pp. 10–27, 2013. View at Publisher · View at Google Scholar · View at Scopus
  3. J. Stein-Streilein, “Immune regulation and the eye,” Trends in Immunology, vol. 29, no. 11, pp. 548–554, 2008. View at Publisher · View at Google Scholar · View at Scopus
  4. J. A. Alvarado, L. J. Katz, S. Trivedi, and A. S. Shifera, “Monocyte modulation of aqueous outflow and recruitment to the trabecular meshwork following selective laser trabeculoplasty,” Archives of Ophthalmology, vol. 128, no. 6, pp. 731–737, 2010. View at Publisher · View at Google Scholar · View at Scopus
  5. R. N. Weinreb, T. Aung, and F. A. Medeiros, “The pathophysiology and treatment of glaucoma: a review,” The Journal of the American Medical Association, vol. 311, no. 18, pp. 1901–1911, 2014. View at Publisher · View at Google Scholar · View at Scopus
  6. Y.-C. Tham, X. Li, T. Y. Wong, H. A. Quigley, T. Aung, and C.-Y. Cheng, “Global prevalence of glaucoma and projections of glaucoma burden through 2040: a systematic review and meta-analysis,” Ophthalmology, vol. 121, no. 11, pp. 2081–2090, 2014. View at Publisher · View at Google Scholar · View at Scopus
  7. M. T. Leite, L. M. Sakata, and F. A. Medeiros, “Managing glaucoma in developing countries,” Arquivos Brasileiros de Oftalmologia, vol. 74, no. 2, pp. 83–84, 2011. View at Publisher · View at Google Scholar · View at Scopus
  8. A. P. Rotchford, J. F. Kirwan, M. A. Muller, G. J. Johnson, and P. Roux, “Temba glaucoma study: a population-based cross-sectional survey in urban South Africa,” Ophthalmology, vol. 110, no. 2, pp. 376–382, 2003. View at Publisher · View at Google Scholar · View at Scopus
  9. P. J. Foster, R. Buhrmann, H. A. Quigley, and G. J. Johnson, “The definition and classification of glaucoma in prevalence surveys,” British Journal of Ophthalmology, vol. 86, no. 2, pp. 238–242, 2002. View at Publisher · View at Google Scholar · View at Scopus
  10. M. Mozaffarieh, S. Fraenkl, K. Konieczka, and J. Flammer, “Targeted preventive measures and advanced approaches in personalised treatment of glaucoma neuropathy,” The EPMA Journal, vol. 1, no. 2, pp. 229–235, 2010. View at Publisher · View at Google Scholar · View at Scopus
  11. M. Malihi, E. R. Moura Filho, D. O. Hodge, and A. J. Sit, “Long-term trends in glaucoma-related blindness in Olmsted County, Minnesota,” Ophthalmology, vol. 121, no. 1, pp. 134–141, 2014. View at Publisher · View at Google Scholar · View at Scopus
  12. M. V. Boland and H. A. Quigley, “Risk factors and open-angle glaucoma: classification and application,” Journal of Glaucoma, vol. 16, no. 4, pp. 406–418, 2007. View at Publisher · View at Google Scholar · View at Scopus
  13. J. M. Tielsch, J. Katz, K. Singh et al., “A population-based evaluation of glaucoma screening: the baltimore eye survey,” American Journal of Epidemiology, vol. 134, no. 10, pp. 1102–1110, 1991. View at Google Scholar · View at Scopus
  14. W. D. Stamer and T. S. Acott, “Current understanding of conventional outflow dysfunction in glaucoma,” Current Opinion in Ophthalmology, vol. 23, no. 2, pp. 135–143, 2012. View at Publisher · View at Google Scholar · View at Scopus
  15. S. D. Crish and D. J. Calkins, “Central visual pathways in glaucoma: evidence for distal mechanisms of neuronal self-repair,” Journal of Neuro-Ophthalmology, vol. 35, supplement 1, pp. S29–S37, 2015. View at Google Scholar
  16. J. C. Morrison, E. C. Johnson, W. Cepurna, and L. Jia, “Understanding mechanisms of pressure-induced optic nerve damage,” Progress in Retinal and Eye Research, vol. 24, no. 2, pp. 217–240, 2005. View at Publisher · View at Google Scholar · View at Scopus
  17. E. Dekeyster, E. Geeraerts, T. Buyens et al., “Tackling glaucoma from within the brain: an unfortunate interplay of BDNF and TrkB,” PLoS ONE, vol. 10, no. 11, Article ID e0142067, 2015. View at Publisher · View at Google Scholar
  18. D. M. Inman, R. M. Sappington, P. J. Horner, and D. J. Calkins, “Quantitative correlation of optic nerve pathology with ocular pressure and corneal thickness in the DBA/2 mouse model of glaucoma,” Investigative Ophthalmology and Visual Science, vol. 47, no. 3, pp. 986–996, 2006. View at Publisher · View at Google Scholar · View at Scopus
  19. R. N. Weinreb, D. S. Friedman, R. D. Fechtner et al., “Risk assessment in the management of patients with ocular hypertension,” American Journal of Ophthalmology, vol. 138, no. 3, pp. 458–467, 2004. View at Publisher · View at Google Scholar · View at Scopus
  20. A. Sommer, J. M. Tielsch, J. Katz et al., “Relationship between intraocular pressure and primary open angle glaucoma among white and black Americans. The Baltimore Eye Survey,” Archives of Ophthalmology, vol. 109, no. 8, pp. 1090–1095, 1991. View at Publisher · View at Google Scholar · View at Scopus
  21. T. S. Acott, M. J. Kelley, K. E. Keller et al., “Intraocular pressure homeostasis: maintaining balance in a high-pressure environment,” Journal of Ocular Pharmacology and Therapeutics, vol. 30, no. 2-3, pp. 94–101, 2014. View at Publisher · View at Google Scholar · View at Scopus
  22. H. A. Quigley, “Neuronal death in glaucoma,” Progress in Retinal and Eye Research, vol. 18, no. 1, pp. 39–57, 1999. View at Publisher · View at Google Scholar · View at Scopus
  23. N. Wang, S. K. Chintala, M. E. Fini, and J. S. Schuman, “Activation of a tissue-specific stress response in the aqueous outflow pathway of the eye defines the glaucoma disease phenotype,” Nature Medicine, vol. 7, no. 3, pp. 304–309, 2001. View at Publisher · View at Google Scholar · View at Scopus
  24. S. J. McKinnon, “The cell and molecular biology of glaucoma: common neurodegenerative pathways and relevance to glaucoma,” Investigative Ophthalmology & Visual Science, vol. 53, no. 5, pp. 2485–2487, 2012. View at Publisher · View at Google Scholar · View at Scopus
  25. I. Soto and G. R. Howell, “The complex role of neuroinflammation in glaucoma,” Cold Spring Harbor Perspectives in Medicine, vol. 4, no. 8, Article ID a017269, 2014. View at Publisher · View at Google Scholar
  26. R. W. Nickells, G. R. Howell, I. Soto, and S. W. M. John, “Under pressure: cellular and molecular responses during glaucoma, a common neurodegeneration with axonopathy,” Annual Review of Neuroscience, vol. 35, pp. 153–179, 2012. View at Publisher · View at Google Scholar · View at Scopus
  27. R. C. Tripathi, R. C. Tripathi, J. Li et al., “Aqueous humor in glaucomatous eyes contains an increased level of TGF-β2,” Experimental Eye Research, vol. 59, no. 6, pp. 723–728, 1994. View at Publisher · View at Google Scholar · View at Scopus
  28. M. Inatani, H. Tanihara, H. Katsuta, M. Honjo, N. Kido, and Y. Honda, “Transforming growth factor-β2 levels in aqueous humor of glaucomatous eyes,” Graefe's Archive for Clinical and Experimental Ophthalmology, vol. 239, no. 2, pp. 109–113, 2001. View at Publisher · View at Google Scholar · View at Scopus
  29. J. Kuchtey, K. A. Rezaei, P. Jaru-Ampornpan, P. Sternberg Jr., and R. W. Kuchtey, “Multiplex cytokine analysis reveals elevated concentration of interleukin-8 in glaucomatous aqueous humor,” Investigative Ophthalmology & Visual Science, vol. 51, no. 12, pp. 6441–6447, 2010. View at Publisher · View at Google Scholar · View at Scopus
  30. Y. Takai, M. Tanito, and A. Ohira, “Multiplex cytokine analysis of aqueous humor in eyes with primary open-angle glaucoma, exfoliation glaucoma, and cataract,” Investigative Ophthalmology and Visual Science, vol. 53, no. 1, pp. 241–247, 2012. View at Publisher · View at Google Scholar · View at Scopus
  31. J. Chua, M. Vania, C. M. Cheung et al., “Expression profile of inflammatory cytokines in aqueous from glaucomatous eyes,” Molecular Vision, vol. 18, pp. 431–338, 2012. View at Google Scholar
  32. J. Freedman and P. Iserovich, “Pro-inflammatory cytokines in glaucomatous aqueous and encysted Molteno implant blebs and their relationship to pressure,” Investigative Ophthalmology & Visual Science, vol. 54, no. 7, pp. 4851–4855, 2013. View at Publisher · View at Google Scholar · View at Scopus
  33. L. A. Engel, P. S. Muether, S. Fauser, and A. Hueber, “The effect of previous surgery and topical eye drops for primary open-angle glaucoma on cytokine expression in aqueous humor,” Graefe's Archive for Clinical and Experimental Ophthalmology, vol. 252, no. 5, pp. 791–799, 2014. View at Publisher · View at Google Scholar · View at Scopus
  34. X. Kong, X. Liu, X. Huang, Z. Mao, Y. Zhong, and W. Chi, “Damage to the blood-aqueous barrier in eyes with primary angle closure glaucoma,” Molecular Vision, vol. 16, pp. 2026–2032, 2010. View at Google Scholar · View at Scopus
  35. B. I. Gallego, J. J. Salazar, R. de Hoz et al., “IOP induces upregulation of GFAP and MHC-II and microglia reactivity in mice retina contralateral to experimental glaucoma,” Journal of Neuroinflammation, vol. 9, article 92, 2012. View at Publisher · View at Google Scholar · View at Scopus
  36. B. Rojas, B. I. Gallego, A. I. Ramirez et al., “Microglia in mouse retina contralateral to experimental glaucoma exhibit multiple signs of activation in all retinal layers,” Journal of Neuroinflammation, vol. 11, article 133, 2014. View at Publisher · View at Google Scholar
  37. M. H. Kuehn, “Immune phenomena in glaucoma and conformational disorders: why is the second eye not involved?” Journal of Glaucoma, vol. 23, pp. S59–S61, 2014. View at Publisher · View at Google Scholar
  38. L. Yuan and A. H. Neufeld, “Tumor necrosis factor-α: a potentially neurodestructive cytokine produced by glia in the human glaucomatous optic nerve head,” Glia, vol. 32, no. 1, pp. 42–50, 2000. View at Publisher · View at Google Scholar · View at Scopus
  39. X. Yan, G. Tezel, M. B. Wax, and D. P. Edward, “Matrix metalloproteinases and tumor necrosis factor α in glaucomatous optic nerve head,” Archives of Ophthalmology, vol. 118, no. 5, pp. 666–673, 2000. View at Publisher · View at Google Scholar · View at Scopus
  40. G. Tezel, L. Y. Li, R. V. Patil, and M. B. Wax, “TNF-α and TNF-α receptor-1 in the retina of normal and glaucomatous eyes,” Investigative Ophthalmology and Visual Science, vol. 42, no. 8, pp. 1787–1794, 2001. View at Google Scholar · View at Scopus
  41. J. D. Stein, N. Talwar, J. H. Kang, O. I. Okereke, J. L. Wiggs, and L. R. Pasquale, “Bupropion use and risk of open-angle glaucoma among enrollees in a large U.S. managed care network,” PLoS ONE, vol. 10, no. 4, Article ID e0123682, 2015. View at Publisher · View at Google Scholar
  42. M. Roh, Y. Zhang, Y. Murakami et al., “Etanercept, a widely used inhibitor of tumor necrosis factor-α (TNF- α), prevents retinal ganglion cell loss in a rat model of glaucoma,” PLoS ONE, vol. 7, no. 7, Article ID e40065, 2012. View at Publisher · View at Google Scholar · View at Scopus
  43. K. E. Keller, Y.-F. Yang, Y. Y. Sun et al., “Interleukin-20 receptor expression in the trabecular meshwork and its implication in glaucoma,” Journal of Ocular Pharmacology and Therapeutics, vol. 30, no. 2-3, pp. 267–276, 2014. View at Publisher · View at Google Scholar · View at Scopus
  44. M. K. Wirtz, J. R. Samples, P. L. Kramer et al., “Mapping a gene for adult-onset primary open-angle glaucoma to chromosome 3q,” American Journal of Human Genetics, vol. 60, no. 2, pp. 296–304, 1997. View at Google Scholar · View at Scopus
  45. J. R. Samples, G. Kitsos, E. Economou-Petersen et al., “Refining the primary open-angle glaucoma GLC1C region on chromosome 3 by haplotype analysis,” Clinical Genetics, vol. 65, no. 1, pp. 40–44, 2004. View at Publisher · View at Google Scholar · View at Scopus
  46. N. J. Logsdon, A. Deshpande, B. D. Harris, K. R. Rajashankar, and M. R. Walter, “Structural basis for receptor sharing and activation by interleukin-20 receptor-2 (IL-20R2) binding cytokines,” Proceedings of the National Academy of Sciences of the United States of America, vol. 109, no. 31, pp. 12704–12709, 2012. View at Publisher · View at Google Scholar · View at Scopus
  47. S. Rutz, X. Wang, and W. Ouyang, “The IL-20 subfamily of cytokines—from host defence to tissue homeostasis,” Nature Reviews. Immunology, vol. 14, no. 12, pp. 783–795, 2014. View at Publisher · View at Google Scholar · View at Scopus
  48. U. M. Wegenka, “IL-20: biological functions mediated through two types of receptor complexes,” Cytokine and Growth Factor Reviews, vol. 21, no. 5, pp. 353–363, 2010. View at Publisher · View at Google Scholar · View at Scopus
  49. U. R. Chowdhury, B. J. Madden, M. C. Charlesworth, and M. P. Fautsch, “Proteome analysis of human aqueous humor,” Investigative Ophthalmology & Visual Science, vol. 51, no. 10, pp. 4921–4931, 2010. View at Publisher · View at Google Scholar · View at Scopus
  50. G. R. Howell, D. O. Walton, B. L. King, R. T. Libby, and S. W. M. John, “Datgan, a reusable software system for facile interrogation and visualization of complex transcription profiling data,” BMC Genomics, vol. 12, article 429, 2011. View at Publisher · View at Google Scholar · View at Scopus
  51. J. Parrish-Novak, W. Xu, T. Brender et al., “Interleukins 19, 20, and 24 signal through two distinct receptor complexes. Differences in receptor-ligand interactions mediate unique biological functions,” The Journal of Biological Chemistry, vol. 277, no. 49, pp. 47517–47523, 2002. View at Publisher · View at Google Scholar · View at Scopus
  52. C. Chang, E. Magracheva, S. Kozlov et al., “Crystal structure of interleukin-19 defines a new subfamily of helical cytokines,” The Journal of Biological Chemistry, vol. 278, no. 5, pp. 3308–3313, 2003. View at Publisher · View at Google Scholar · View at Scopus
  53. E. C. Johnson, T. A. Doser, W. O. Cepurna et al., “Cell proliferation and interleukin-6-type cytokine signaling are implicated by gene expression responses in early optic nerve head injury in rat glaucoma,” Investigative Ophthalmology & Visual Science, vol. 52, no. 1, pp. 504–518, 2011. View at Publisher · View at Google Scholar · View at Scopus
  54. Y. Huang, L.-P. Cen, K. W. Choy et al., “JAK/STAT pathway mediates retinal ganglion cell survival after acute ocular hypertension but not under normal conditions,” Experimental Eye Research, vol. 85, no. 5, pp. 684–695, 2007. View at Publisher · View at Google Scholar · View at Scopus
  55. D. A. Braun, M. Fribourg, and S. C. Sealfon, “Cytokine response is determined by duration of receptor and signal transducers and activators of transcription 3 (STAT3) activation,” The Journal of Biological Chemistry, vol. 288, no. 5, pp. 2986–2993, 2013. View at Publisher · View at Google Scholar · View at Scopus
  56. J. Gaffney, I. Solomonov, E. Zehorai, and I. Sagi, “Multilevel regulation of matrix metalloproteinases in tissue homeostasis indicates their molecular specificity in vivo,” Matrix Biology, vol. 44–46, pp. 191–99, 2015. View at Publisher · View at Google Scholar · View at Scopus
  57. Y.-H. Hsu, C.-H. Hsing, C.-F. Li et al., “Anti-IL-20 monoclonal antibody suppresses breast cancer progression and bone osteolysis in murine models,” The Journal of Immunology, vol. 188, no. 4, pp. 1981–1991, 2012. View at Publisher · View at Google Scholar · View at Scopus
  58. K.-Y. Huang, R.-M. Lin, W.-Y. Chen, C.-L. Lee, J.-J. Yan, and M.-S. Chang, “IL-20 may contribute to the pathogenesis of human intervertebral disc herniation,” Spine, vol. 33, no. 19, pp. 2034–2040, 2008. View at Publisher · View at Google Scholar · View at Scopus
  59. K. E. Keller, M. Aga, J. M. Bradley, M. J. Kelley, and T. S. Acott, “Extracellular matrix turnover and outflow resistance,” Experimental Eye Research, vol. 88, no. 4, pp. 676–682, 2009. View at Publisher · View at Google Scholar · View at Scopus
  60. J. M. B. Bradley, M. J. Kelley, X. Zhu, A. M. Anderssohn, J. P. Alexander, and T. S. Acott, “Effects of mechanical stretching on trabecular matrix metalloproteinases,” Investigative Ophthalmology and Visual Science, vol. 42, no. 7, pp. 1505–1513, 2001. View at Google Scholar · View at Scopus
  61. J. M. B. Bradley, J. Vranka, C. M. Colvis et al., “Effect of matrix metalloproteinases activity on outflow in perfused human organ culture,” Investigative Ophthalmology & Visual Science, vol. 39, no. 13, pp. 2649–2658, 1998. View at Google Scholar · View at Scopus
  62. D.-J. Oh, M. H. Kang, Y. H. Ooi, K. R. Choi, E. H. Sage, and D. J. Rhee, “Overexpression of SPARC in human trabecular meshwork increases intraocular pressure and alters extracellular matrix,” Investigative Ophthalmology and Visual Science, vol. 54, no. 5, pp. 3309–3319, 2013. View at Publisher · View at Google Scholar · View at Scopus
  63. J. A. Vranka, M. J. Kelley, T. S. Acott, and K. E. Keller, “Extracellular matrix in the trabecular meshwork: intraocular pressure regulation and dysregulation in glaucoma,” Experimental Eye Research, vol. 133, pp. 112–125, 2015. View at Publisher · View at Google Scholar
  64. D. S. Aaronson and C. M. Horvath, “A road map for those who don't know JAK-STAT,” Science, vol. 296, no. 5573, pp. 1653–1655, 2002. View at Publisher · View at Google Scholar · View at Scopus
  65. J.-S. Mo, M. G. Anderson, M. Gregory et al., “By altering ocular immune privilege, bone marrow-derived cells pathogenically contribute to DBA/2J pigmentary glaucoma,” The Journal of Experimental Medicine, vol. 197, no. 10, pp. 1335–1344, 2003. View at Publisher · View at Google Scholar · View at Scopus
  66. B. Chang, R. S. Smith, N. L. Hawes et al., “Interacting loci cause severe iris atrophy and glaucoma in DBA/2J mice,” Nature Genetics, vol. 21, no. 4, pp. 405–409, 1999. View at Publisher · View at Google Scholar · View at Scopus
  67. M. G. Anderson, R. S. Smith, N. L. Hawes et al., “Mutations in genes encoding melanosomal proteins cause pigmentary glaucoma in DBA/2J mice,” Nature Genetics, vol. 30, no. 1, pp. 81–85, 2002. View at Publisher · View at Google Scholar · View at Scopus
  68. J. H. Ahn, Y. Lee, C. Jeon et al., “Identification of the genes differentially expressed in human dendritic cell subsets by cDNA subtraction and microarray analysis,” Blood, vol. 100, no. 5, pp. 1742–1754, 2002. View at Google Scholar · View at Scopus
  69. S. Shikano, M. Bonkobara, P. K. Zukas, and K. Ariizumi, “Molecular cloning of a dendritic cell-associated transmembrane protein, DC-HIL, that promotes RGD-dependent adhesion of endothelial cells through recognition of heparan sulfate proteoglycans,” The Journal of Biological Chemistry, vol. 276, no. 11, pp. 8125–8134, 2001. View at Publisher · View at Google Scholar · View at Scopus
  70. K. Yamaki, K. Gocho, K. Hayakawa, I. Kondo, and S. Sakuragi, “Tyrosinase family proteins are antigens specific to Vogt-Koyanagi-Harada disease,” Journal of Immunology, vol. 165, no. 12, pp. 7323–7329, 2000. View at Publisher · View at Google Scholar · View at Scopus
  71. R. T. Libby, M. G. Anderson, I.-H. Pang et al., “Inherited glaucoma in DBA/2J mice: pertinent disease features for studying the neurodegeneration,” Visual Neuroscience, vol. 22, no. 5, pp. 637–648, 2005. View at Publisher · View at Google Scholar · View at Scopus
  72. W. Fan, X. Li, W. Wang, J. S. Mo, H. Kaplan, and N. G. F. Cooper, “Early involvement of immune/inflammatory response genes in retinal degeneration in DBA/2J mice,” Ophthalmology and Eye Diseases, vol. 1, pp. 23–41, 2010. View at Publisher · View at Google Scholar
  73. M. G. Anderson, R. T. Libby, D. B. Gould, R. S. Smith, and S. W. M. John, “High-dose radiation with bone marrow transfer prevents neurodegeneration in an inherited glaucoma,” Proceedings of the National Academy of Sciences of the United States of America, vol. 102, no. 12, pp. 4566–4571, 2005. View at Publisher · View at Google Scholar · View at Scopus
  74. A. Bosco, S. D. Crish, M. R. Steele et al., “Early reduction of microglia activation by irradiation in a model of chronic glaucoma,” PLoS ONE, vol. 7, no. 8, Article ID e43602, 2012. View at Publisher · View at Google Scholar · View at Scopus
  75. A. Bosco, M. R. Steele, and M. L. Vetter, “Early microglia activation in a mouse model of chronic glaucoma,” Journal of Comparative Neurology, vol. 519, no. 4, pp. 599–620, 2011. View at Publisher · View at Google Scholar · View at Scopus
  76. H. Horiuchi, B. Parajuli, Y. Wang et al., “Interleukin-19 acts as a negative autocrine regulator of activated microglia,” PLoS ONE, vol. 10, no. 3, Article ID e0118640, 2015. View at Publisher · View at Google Scholar
  77. G. R. Howell, I. Soto, X. Zhu et al., “Radiation treatment inhibits monocyte entry into the optic nerve head and prevents neuronal damage in a mouse model of glaucoma,” The Journal of Clinical Investigation, vol. 122, no. 4, pp. 1246–1261, 2012. View at Publisher · View at Google Scholar · View at Scopus
  78. A. Bosco, D. M. Inman, M. R. Steele et al., “Reduced retina microglial activation and improved optic nerve integrity with minocycline treatment in the DBA/2J mouse model of glaucoma,” Investigative Ophthalmology and Visual Science, vol. 49, no. 4, pp. 1437–1446, 2008. View at Publisher · View at Google Scholar · View at Scopus
  79. E. C. Johnson and J. C. Morrison, “Friend or foe? Resolving the impact of glial responses in glaucoma,” Journal of Glaucoma, vol. 18, no. 5, pp. 341–353, 2009. View at Publisher · View at Google Scholar · View at Scopus
  80. C. F. Burgoyne and J. C. Morrison, “The anatomy and pathophysiology of the optic nerve head in glaucoma,” Journal of Glaucoma, vol. 10, no. 5, pp. S16–S18, 2001. View at Publisher · View at Google Scholar · View at Scopus
  81. J. C. Downs, J.-K. F. Suh, K. A. Thomas, A. J. Bellezza, R. T. Hart, and C. F. Burgoyne, “Viscoelastic material properties of the peripapillary sclera in normal and early-glaucoma monkey eyes,” Investigative Ophthalmology and Visual Science, vol. 46, no. 2, pp. 540–546, 2005. View at Publisher · View at Google Scholar · View at Scopus