Association of Heme Oxygenase 1 with Lung Protection in Malaria-Associated ALI/ARDS

Figure 2

Hemin treatment protects Plasmodium berghei-infected DBA/2 mice from ALI/ARDS. Mice were treated with hemin on days 2 and 4 after infection. (a) Parasitemias of mice treated with hemin or saline (unpaired t-test, , ). (b) Survival curve of mice treated with hemin or saline (log-rank test, , ). (c) Representative figures of necropsies and histological lung sections of noninfected mice (top); hemin treated mice, on the 7th day after infection (middle); and saline treated mice (bottom). Scale bars: left column: 50 μm; right column: 20 μm; (d) alveolar area percentage in hemin treated versus saline treated mice (Mann–Whitney test, , ).