Association of Heme Oxygenase 1 with Lung Protection in Malaria-Associated ALI/ARDS

Figure 3

Induction of HO-1 improves Plasmodium berghei-infected DBA/2 respiratory parameters and lowers inflammatory cytokines levels. Mice were treated with hemin on days 2 and 4 after infection. ((a) and (b)) Respiratory pause and respiratory frequency of the animals treated and untreated after 7th DAI (unpaired t-test, , ). (c) IFN-γ quantitative RT-PCR assay of mice lung tissue (unpaired t-test, , ). ((d) to (h)) Protein levels of the cytokines IFN-γ, IL-10, MCP-1, and TNF-α in the serum and lung determined by CBA (unpaired t-test, , , , and ).

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