A Mutation in IL4RA Is Associated with the Degree of Pathology in Human TB Patients

Figure 2

Decreased susceptibility of IL-4Rα^−/− mice to Mtb. BALB/c (white circles), (black circles), and IL-4Rα^−/−  (black rhombs) mice were infected with 100 CFU Mtb H37Rv per aerosol. At different time points CFU was determined in lung homogenates. Data represent means and standard deviations of 4-5 mice ( for comparison of and BALB/c mice; for comparison of and IL-4Rα^−/− mice; nonparametric ANOVA with Dunn’s Multiple Comparison Test). One experiment representative of two performed is shown.