Research Article

A Mutation in IL4RA Is Associated with the Degree of Pathology in Human TB Patients

Table 1

Genotype frequencies of variants of the IL4, IL4R, IL13, IL13RA1, and IL13RA2 genes in TB cases stratified for the size and number of cavities in chest radiographs.

Gene variantCavity scoreOR95% CIp
0123

IL4-589 rs2243250 79632509186
 CC63.3%55.7%54.2%57.0%1
 CT32.9%37.7%38.9%37.1%0.960.6–1.50.85
 TT3.8%6.6%6.9%5.9%0.890.6–1.30.58

IL13-1112 rs180092581649517189
 CC 29.6%29.7%34.0%28.0%1
 CT51.9%50.4%49.9%53.5%1.000.8–1.30.97
 TT18.5%19.9%16.1%18.5%0.860.6–1.10.31

IL4R I50V rs180501082649518191
 GG28.0%26.0%24.1%25.1%1
 AG56.1%51.5%51.5%45.0%0.990.8–1.30.92
 AA15.9%22.5%24.3%29.8%1.321.0–1.70.05
 GG/AG84.2%77.5%75.7%70.2%1
 AA15.9%22.5%24.3%29.8%1.331.1–1.7

IL13RA1 rs24956362722614051
 Female
 AA88.9%86.3%85.7%84.3%1
 AG11.1%13.7%14.3%11.8%1.170.7–2.00.55
 GG0.0%0.0%0.0%3.9%nc

IL13RA2 rs59460402722714051
 Female
 GG48.1%47.1%47.9%31.4%1
 GT44.4%40.1%43.6%52.9%1.260.9–1.90.24
 TT7.4%12.8%8.6%15.7%0.900.5–1.70.74

IL13RA1 rs249563657424380137
 Male
 A91.2%93.4%94.2%90.5%1
 G8.8%6.6%5.8%9.5%1.130.7–1.80.62

IL13RA2 rs594604057420375138
 Male
 G59.6%71.0%69.1%71.7%1
 T40.4%29.1%30.9%28.3%0.930.7–1.20.59

Odds ratios (OR) and 95% confidence intervals (CI) were calculated by ordinal logistic regression. nc, not calculable. As the IL13RA1 and the IL13RA2 genes are located on the X-chromosome, association testing was performed separately for males and females. Genotype frequencies of IL4R I50V in TB cases stratified for the size and number of cavities assuming a recessive mode of inheritance are followed by asterisk.