A Mutation in IL4RA Is Associated with the Degree of Pathology in Human TB Patients
Table 1
Genotype frequencies of variants of the IL4, IL4R, IL13, IL13RA1, and IL13RA2 genes in TB cases stratified for the size and number of cavities in chest radiographs.
Gene variant
Cavity score
OR
95% CI
p
0
1
2
3
IL4-589 rs2243250
79
632
509
186
CC
63.3%
55.7%
54.2%
57.0%
1
CT
32.9%
37.7%
38.9%
37.1%
0.96
0.6–1.5
0.85
TT
3.8%
6.6%
6.9%
5.9%
0.89
0.6–1.3
0.58
IL13-1112 rs1800925
81
649
517
189
CC
29.6%
29.7%
34.0%
28.0%
1
CT
51.9%
50.4%
49.9%
53.5%
1.00
0.8–1.3
0.97
TT
18.5%
19.9%
16.1%
18.5%
0.86
0.6–1.1
0.31
IL4R I50V rs1805010
82
649
518
191
GG
28.0%
26.0%
24.1%
25.1%
1
AG
56.1%
51.5%
51.5%
45.0%
0.99
0.8–1.3
0.92
AA
15.9%
22.5%
24.3%
29.8%
1.32
1.0–1.7
0.05
GG/AG
84.2%
77.5%
75.7%
70.2%
1
AA
15.9%
22.5%
24.3%
29.8%
1.33
1.1–1.7
IL13RA1 rs2495636
27
226
140
51
Female
AA
88.9%
86.3%
85.7%
84.3%
1
AG
11.1%
13.7%
14.3%
11.8%
1.17
0.7–2.0
0.55
GG
0.0%
0.0%
0.0%
3.9%
nc
IL13RA2 rs5946040
27
227
140
51
Female
GG
48.1%
47.1%
47.9%
31.4%
1
GT
44.4%
40.1%
43.6%
52.9%
1.26
0.9–1.9
0.24
TT
7.4%
12.8%
8.6%
15.7%
0.90
0.5–1.7
0.74
IL13RA1 rs2495636
57
424
380
137
Male
A
91.2%
93.4%
94.2%
90.5%
1
G
8.8%
6.6%
5.8%
9.5%
1.13
0.7–1.8
0.62
IL13RA2 rs5946040
57
420
375
138
Male
G
59.6%
71.0%
69.1%
71.7%
1
T
40.4%
29.1%
30.9%
28.3%
0.93
0.7–1.2
0.59
Odds ratios (OR) and 95% confidence intervals (CI) were calculated by ordinal logistic regression. nc, not calculable. As the IL13RA1 and the IL13RA2 genes are located on the X-chromosome, association testing was performed separately for males and females. Genotype frequencies of IL4R I50V in TB cases stratified for the size and number of cavities assuming a recessive mode of inheritance are followed by asterisk.