Effect of Previous High Glutamine Infusion on Inflammatory Mediators and Mortality in an Acute Pancreatitis Model

Table 1

Serum cytokine levels in rats with acute pancreatitis, according to treatment and time point.

Cytokine	Treatment	Time point
		2 h				12 h				24 h
		Median	1°  quartile	3°  quartile	p  value	Median	1°  quartile	3°  quartile	p  value	Median	1°  quartile	3°  quartile	p  value
IL-1a	Saline	14.41	4.67	47.89	0.552	15.60	11.40	31.86	0.574	1.84	1.84	46.08	0.583
	Glutamine	4.67	4.67	12.27		13.57	9.48	33.94		12.49	1.84	25.98
	Nontreatment	8.47	4.67	47.89		8.57	6.13	17.86		72.61	1.84	128.00
IL-4	Saline	3.98	3.98	8.90	0.970	5.91	4.88	9.23	0.464	1.30	1.30	13.10	0.398
	Glutamine	3.98	3.98	3.98		5.91	3.91	15.38		1.30	1.30	4.88
	Nontreatment	3.98	3.98	3.98		2.17	1.35	6.98		19.72	1.30	42.82
IL-2	Saline	25.50	22.32	31.21	0.833	49.40	10.97	72.34	0.814	74.03	27.12	117.21	0.249
	Glutamine	23.89	22.31	30.38		46.75	18.16	90.19		70.94	17.49	167.75
	Non-treatment	23.10	17.69	33.71		37.89	24.44	48.50		135.50	83.31	166.00
IL-6	Saline	200.00	76.71	289.50	0.644	220.00	50.13	12704.00	0.971	369.00	184.21	766.50	0.458
	Glutamine	178.00	33.11	452.00		331.25	29.70	1619.00		903.00	486.50	1089.00
	Nontreatment	336.00	33.11	3135.00		1789.00	113.00	5319.00		464.50	293.00	599.00
IL-10	Saline	400.00	294.50	560.00	0.288	142.00	99.08	691.00	0.964	65.83	34.62	183.18	0.553
	Glutamine	539.00	298.00	893.00		482.50	65.28	1521.00		77.82	54.16	125.41
	Nontreatment	336.50	168.00	482.00		273.00	96.09	617.00		51.42	39.50	57.66
IFN-γ	Saline	72.62	30.44	89.41	0.142	6.50	6.50	6.50	0.908	4.01	4.01	4.01	0.776
	Glutamine	55.67	55.67	64.15		6.50	6.50	6.50		4.01	4.01	4.01
	Nontreatment	85.25	64.15	93.61		6.50	6.50	6.50		4.01	4.01	63.08
TNF-	Saline	8.44	1.82	15.97	0.390	4.84	2.17	5.86	0.862	13.02	9.19	23.27	0.579
	Glutamine	11.22	1.82	11.22		3.91	2.17	8.05		16.31	3.94	18.50
	Nontreatment	1.82	1.82	8.53		4.19	2.43	9.21		22.27	14.12	38.39

IL, interleukin; INF, interferon; TNF, tumor necrosis factor.