Parallel Aspects of the Microenvironment in Cancer and Autoimmune Disease

Table 2

Examples for the distribution of macrophages and neutrophils in different types of cancer and autoimmune diseases.

Type of carcinoma	Localization	Percentage (%)	Mice/human	Ref
Macrophages in cancer
Mammary gland; Gastrointestinal tumors; Diffuse large B-cell lymphoma; Non-small-cell lung cancer (NSCLC)	Macrophages are found infiltrating all areas of the tumors (including the perinecroptic areas); Many macrophages are found in the stroma, in close contact with the cancer cells	>40%; <30%; 20%; 15%–30%	Mice; Human; Human; Human	[22]; [23]; [24]; [25, 26]
Prostate cancer	In stroma and in close contact with cancer cells	10%–15%	Human	[27]
Pancreatic cancer	Intratumoral and in the invasive front	30–50%	Human	[28]
Colon cancer	Intratumoral, numbers increase with tumor stage and grade	25%–50%	Human	[29]
L929 Fibrosarcoma, B16 melanoma, LLC lung carcinoma cells	Intratumoral	23–51%	Mice	[30]
Neutrophils in cancer
Lung cancer	Infiltrating the tumor	8%	Human	[31]
Clear cell renal cell carcinoma (RCC)	Intratumoral or near vessels	14%	Human	[32]
Mesothelioma, lung cancer	Intratumoral	0.7–2.5%	Mice	[33]
L929 Fibrosarcoma, B16 melanoma, LLC lung carcinoma cells	Intratumoral or near vessels	3–8%	Mice	[30]
Macrophages in autoimmune diseases
Rheumatoid arthritis (RA)	Lining the synovial membrane	41%	Human	[34]
	Lining and infiltrating the synovium	35–46%	Human	[35]
	Lining and infiltrating the synovium	17–36%	Human	[36]
	Infiltrating the synovium	26%	Human	[37]
Multiple sclerosis (MS)	Infiltrating and at the rim of the lesion	15–30%	Human	[38]
Systemic lupus (SLE)	Kidney: infiltrating all parenchyma, found surrounding glomeruli and around perivascular aggregate	26%	Mice	[39]
Systemic lupus (SLE)	Throughout the nephritic kidney	4%	Mice	[40]
Scleroderma	Skin	23%	Rat	[41]
Systemic sclerosis (SSc)	Superficial and deep dermis at early stages	13%	Human	[42]
Neutrophils in autoimmune diseases
Rheumatoid arthritis (RA)	Lining and infiltrating the synovium	8–15%	Human	[35]
	Infiltrating the synovium	4.5–7%	Human	[37]
Experimental autoimmune encephalomyelitis (EAE)	Within brain lesions; In the spinal cord	0.4–3%; 8%	Mice	[43–45]
Systemic lupus (SLE, juvenile)	CD15^+ low density granulocytes in circulation	10%	Human	[46]