Radiotherapy Suppresses Bone Cancer Pain through Inhibiting Activation of cAMP Signaling in Rat Dorsal Root Ganglion and Spinal Cord

Figure 5

Radiotherapy reduced TCI-induced increase of IL-1β and TNF-α in the spinal cord. IL-1β and TNF-α concentrations were analyzed by ELISA. The tissues were collected on postoperative days 10 and 14, that is, 1 and 5 days after radiotherapy, respectively. Four samples were included in each group and each sample included a segment of the spinal cord at L₄-L₅. versus sham; versus TCI + sham.

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