Serotonin-Exacerbated DSS-Induced Colitis Is Associated with Increase in MMP-3 and MMP-9 Expression in the Mouse Colon

<div>5-HT alone increased MMP-3 and MMP-9 mRNA expressions in mouse colon. The treatment with low-dose 5-HT increased MMP-9 mRNA expression in mouse colon tissues; high dose only increased MMP-3 mRNA. Neither low- nor high-dose 5-HT increased the expression of MMP-2, TIMP-1, or TIMP-2 mRNA. Results are expressed as the mean ± standard deviations (SD) and 8 mice were included for all three groups. 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Mediators of Inflammation

fig3

Figure 3

Figure 3: Serotonin-Exacerbated DSS-Induced Colitis Is Associated with Increase in MMP-3 and MMP-9 Expression in the Mouse Colon 