Serotonin-Exacerbated DSS-Induced Colitis Is Associated with Increase in MMP-3 and MMP-9 Expression in the Mouse Colon

Figure 4

IHC staining of MMP-3 and MMP-9 in mouse colon tissue. The low expression MMP-3 was in colon tissue of control mice. The expression of MMP-3 was increased in the colon tissue of mice treated with high-dose 5-HT, further increased in severe inflammatory tissue. MMP-3 mainly located in infiltrating cells and stromal cells, some epithelial cell having weak staining. MMP-9 was increased in low 5-HT group but not in high-dose group and also highly increased in tissue with severe inflammation. MMP-9 was located mainly in inflammatory cells. Six mice from each group were included for IHC staining.