Serotonin-Exacerbated DSS-Induced Colitis Is Associated with Increase in MMP-3 and MMP-9 Expression in the Mouse Colon

Table 3

5-HT increases cytokine gene expression in mouse colon.

Group	Control	1 mg 5-HT	2 mg 5-HT	1% DSS	1% DSS + 1 mg 5-HT	2.5% DSS
n	8	9	9	14	12	7
IL-6	1 ± 0.1	1.4 ± 0.3	2.6 ± 0.6	144 ± 24.2	1722 ± 415.9	1070 ± 445.1
IL-8	1 ± 0.4	1.3 ± 0.3	3.7 ± 0.6	0.9 ± 0.1	1.8 ± 0.05	1.1 ± 0.1
TNF-α	1 ± 0.2	1.5 ± 0.1	1.7 ± 0.3	5.6 ± 0.8	8.5 ± 1.6	9.8 ± 1.2

P < 0.05 versus control mice.
The data stands for relative fold of cytokine mRNA.