Serotonin-Exacerbated DSS-Induced Colitis Is Associated with Increase in MMP-3 and MMP-9 Expression in the Mouse Colon

Table 4

Analysis of MMPs mRNA in mouse colon.

Group	Control	1% DSS	1% DSS + 1 mg 5-HT	2.5% DSS
MMP-2	1.0 ± 0.04	1.8 ± 0.2	2.9 ± 0.2	6.3 ± 0.3
MMP-3	1.0 ± 0.05	28.1 ± 12.2	218 ± 101.5	170 ± 37
MMP-9	1.0 ± 0.06	11.8 ± 2.0	52.7 ± 9.6	111.4 ± 19.8
TIMP-1	1.0 ± 0.03	9.8 ± 3.5	114.6 ± 27.3	82.1 ± 10.7
TIMP-2	1.0 ± 0.03	1.2 ± 0.2	6.0 ± 1.9	3.8 ± 0.5

P < 0.05 versus control mice.
The data presents 8 mice of each group and stands for relative fold.