Serotonin-Exacerbated DSS-Induced Colitis Is Associated with Increase in MMP-3 and MMP-9 Expression in the Mouse Colon

Table 5

Analysis of MMP-3 and MMP-9 protein levels by IHC in mouse colon.

Group	n	Control	1 mg 5-HT	2 mg 5-HT	1% DSS	1% DSS + 1 mg 5-HT	2.5% DSS
MMP-3	6	0.5 ± 0.5	0.8 ± 1.0	3.7 ± 0.8	5.7 ± 2.0	8.8 ± 2.0	8.2 ± 3.8
MMP-9	6	0.3 ± 0.5	3.0 ± 1.1	0.7 ± 0.8	4.2 ± 1.0	9.0 ± 2.7	7.5 ± 4.2

P < 0.05 versus control mice; P < 0.05 versus 1 mg 5-HT group for MMP-3 or versus 2 mg 5-HT group for MMP-9.