CD4⁺ T Cell Fate in Glomerulonephritis: A Tale of Th1, Th17, and Novel Treg Subtypes

Figure 1

The fate of Th17 cells during glomerulonephritis remains unknown. While some Th17 cells conserve their phenotype, a relevant fraction of Th17 cells seems to change their fate. Currently available data, however, do not support predominant conversion into either Th1 cells or Foxp3⁺ Tregs. An intriguing possibility that remains might be adoption of a Tr1 phenotype.