Research Article

Cardiorenal Involvement in Metabolic Syndrome Induced by Cola Drinking in Rats: Proinflammatory Cytokines and Impaired Antioxidative Protection

Figure 5

Immunohistochemistry of renal glomeruli and tubules before and after cola treatment. Cola treatment (C, top row) resulted in glomerulosclerosis (PAS column) and intense tubular immunopositivity for IL-6 and TNF-α, with no major change in redoxins Trx-1 and Prx-2 immunopositive labelling compared with water drinking rats (W, bottom row). H&E: hematoxylin-eosin, PAS: periodic acid-Schiff, Trx-1: thioredoxin-1, Prx-2: peroxiredoxin-2, IL-6: interleukin-6, and TNF-α: tumor necrosis factor-alpha.