Protective Effect of Galectin-1 during Histoplasma capsulatum Infection Is Associated with Prostaglandin E₂ and Nitric Oxide Modulation

Figure 3

Lgals1^−/− mice have increased neutrophil infiltration in the lung parenchyma. H. capsulatum-infected mice were euthanized on day 15 after infection and lung sections (5 μm) were embedded in paraffin blocks. Lung sections from WT + H. capsulatum (I, bar: 100 μm; III, bar: 25 μm) and Lgals1^−/− + H. capsulatum (II, bar: 100 μm; IV, bar: 25 μm) were stained with hematoxylin (a) and neutrophils were quantified (neutrophils/mm²) using magnifications ×400 (b). Data are representative of one of the two experiments performed independently ( per group). Values are mean ± SEM. WT versus Lgals1^−/−, both infected.

(a)

(b)