CRP and SAA1 Haplotypes Are Associated with Both C-Reactive Protein and Serum Amyloid A Levels: Role of Suppression Effects

Table 3

Associations of the CRP and SAA genotypes with CRP and SAA levels.

	MM	Mm	mm	value (adjusted )	value (adjusted )	MM	Mm + mm	(95% CI)	value (adjusted )	value (adjusted )
CRP SNP and CRP level
rs2794521	1.0 ± 1.3 (393)	1.2 ± 1.6 (176)	1.0 ± 1.1 (21)	0.987	NA	1.0 ± 1.3 (393)	1.2 ± 1.5 (197)	2.49 × 10^−5 (−0.078–0.078)	0.999	NA
rs3091244	0.9 ± 1.2 (374)	1.5 ± 1.7 (39)	1.3 ± 1.6 (178)	4.94 × 10^−6 (2.47 × 10^−5)	NA	0.9 ± 1.2 (374)	1.4 ± 1.6 (217)	−0.179 (−0.253 to −0.105)	2.49 × 10^−6 (1.25 × 10^−5)	NA
rs1800947	1.1 ± 1.4 (512)	0.9 ± 1.5 (83)	0.3 ± 0.2 ()	0.029	NA	1.1 ± 1.4 (512)	0.9 ± 1.5 (85)	0.115 (0.011–0.219)	0.030	NA
rs1130864	1.1 ± 1.4 (557)	1.4 ± 1.7 (39)	0.52 ()	0.096	NA	1.1 ± 1.4 (557)	1.4 ± 1.6 (40)	−0.124 (−0.269–0.021)	0.093	NA
rs1205	0.8 ± 1.2 (197)	1.2 ± 1.4 (305)	1.3 ± 1.6 (88)	3.95 × 10^−5 (1.98 × 10^−4)	NA	0.8 ± 1.2 ()	1.2 ± 1.5 ()	−0.156 (−0.233 to −0.080)	6.28 × 10^−5 (3.13 × 10^−4)	NA
CRP SNP and SAA level
rs2794521	5.6 ± 12.5 (386)	4.9 ± 8.1 (173)	4.6 ± 3.2 (21)	0.896	0.982	5.6 ± 12.5 (386)	4.8 ± 7.7 (194)	0.007 (−0.075–0.088)	0.873	0.951
rs3091244	5.8 ± 13.1 (370)	4.4 ± 2.9 (37)	4.6 ± 6.8 (174)	0.861	0.066	5.8 ± 13.1 (370)	4.5 ± 6.3 (211)	−0.014 (−0.093–0.065)	0.734	0.078
rs1800947	5.1 ± 10.1 (503)	7.0 ± 15.8 (82)	0.4 ± 0.7 ()	0.997	0.358	5.1 ± 10.1 (503)	6.8 ± 15.7 (84)	−0.002 (−0.111–0.117)	0.969	0.339
rs1130864	5.4 ± 11.4 (548)	4.4 ± 3.0 (38)	1.97 ()	0.694	0.698	5.4 ± 11.4 (548)	4.3 ± 2.9 (39)	−0.032 (−0.185–0.121)	0.683	0.705
rs1205	7.0 ± 17.2 (195)	4.3 ± 4.5 (298)	5.1 ± 9.1 (87)	0.906	0.059	7.0 ± 17.2 (195)	4.5 ± 5.9 (385)	0.005 (−0.076–0.086)	0.898	0.064
SAA SNP and SAA level
rs4638289	3.0 ± 4.1 (237)	5.7 ± 10.4 (266)	11.3 ± 21.7 (75)	1.78 × 10^−26 (7.12 × 10^−26)	NA	3.0 ± 4.1 (237)	6.9 ± 13.8 (341)	−0.397 (−0.468 to −0.326)	1.87 × 10^−25 (7.48 × 10^−25)	NA
rs12218	5.9 ± 13.1 (304)	4.7 ± 8.5 (232)	5.5 ± 8.2 (39)	0.415	NA	5.9 ± 13.1 (304)	4.8 ± 8.4 (271)	−0.014 (−0.091–0.064)	0.726	NA
rs7131332	8.0 ± 14.5 (187)	4.4 ± 7.1 (292)	3.2 ± 12.6 (97)	1.45 × 10^−19 (5.80 × 10^−19)	NA	8.0 ± 14.6 (187)	4.1 ± 8.8 (389)	−0.338 (−0.415 to −0.261)	4.83 × 10^−17 (1.93 × 10^−16)	NA
rs11024591	7.9 ± 15.7 (211)	4.4 ± 7.7 (284)	2.0 ± 2.1 (82)	1.01 × 10^−20 (4.04 × 10^−20)	NA	7.9 ± 15.7 ()	3.8 ± 6.9 ()	—	3.21 × 10^−17 (1.28 × 10^−16)	NA
SAA SNP and CRP level
rs4638289	1.1 ± 1.4 (245)	1.0 ± 1.4 (268)	1.3 ± 1.5 (75)	0.663	6.2 × 10^−6; (2.48 × 10^−5)	1.1 ± 1.4 (245)	1.1 ± 1.4 (343)	−0.013 (−0.088–0.062)	0.733	6.03 × 10^−6 (2.41 × 10^−5)
rs12218	1.0 ± 1.4 (308)	1.1 ± 1.3 (238)	1.5 ± 1.7 (39)	0.015	0.024	1.0 ± 1.4 (308)	1.1 ± 1.4 (277)	0.042 (−0.032–0.115)	0.267	0.133
rs7131332	1.2 ± 1.5 (188)	1.0 ± 1.4 (299)	0.9 ± 1.2 (99)	0.202	0.010	1.2 ± 1.5 (188)	1.0 ± 1.3 (398)	−0.087 (−0.165 to −0.009)	0.029	0.193
rs11024591	1.3 ± 1.5 (211)	1.0 ± 1.4 (291)	0.9 ± 1.2 (85)	0.251	0.004	1.3 ± 1.5 (211)	1.0 ± 1.3 (376)	−0.105 (−0.180 to −0.029)	0.007	0.439

M: major allele, m: minor allele, and number of subjects below the CRP/SAA levels.
⁢: adjusted for age, sex, body mass index, smoking, and medications for hypertension, diabetes mellitus, and dyslipidemia, : adjusted for age, sex, body mass index, smoking, and medications for hypertension, diabetes mellitus, and dyslipidemia as well as CRP levels (for CRP genotypes) or SAA levels (for SAA genotypes). Adjusted P: Bonferroni correction for or values, and only significant values were demonstrated.
rs3091244 is a triallelic locus (A, C, and T) and when the genotypes were analyzed separately, value is 8.72 × 10⁻⁵ for CRP level and and values are 0.44 and 0.076, respectively, for SAA levels. The genotypes of rs3091244 were recoded as CC for MM, AA+AC+AT for Mm, and CT+TT for mm in the table [26].