Interaction between Cannabinoid System and Toll-Like Receptors Controls Inflammation

Table 3

Inflammatory effects on endocannabinoid system.

Cell or tissue	Stimulus in vitro or animal model	Effect	Reference
Macrophages	Thioglycollate in vivo	↑ CB2 receptor	Carlisle et al. [128]
Microglial cells	Interferon-γ	Induces CB2 receptor	Walter et al. [129]
			Maresz et al. [130]
Thioglycollate-elicited macrophages	LPS	↓ CB2 receptor	Carlisle et al. [128]
			Cabral et al. [131]
Microglial cells	LPS in vivo	↑ CB2 receptor	Mukhopadhyay et al. [132]
			Concannon et al. [133]
Blood mononuclear cells	LPS in vivo	↓ fatty acid amide hydrolase activity	Wolfson et al. [134]
Spleen & liver	LPS in vivo	↓ 2-arachidonyl glycerol hydrolytic activity	Szafran et al. [135]
Monocytes	LPS	↑ anandamide	Varga et al. [136]
Macrophages	LPS	↑ 2-arachidonyl glycerol	Pestonjamasp and Burstein [137]
		↓ 2-arachidonyl glycerol hydrolytic activity
Dendritic cells	LPS	↑ 2-arachidonyl glycerol	Matias et al. [138]
RAW 264.7 cells	LPS	Induces CB1 receptor	Walter et al. [129]
		↑ CB2 receptor	Mukhopadhyay et al. [132]
			Friedman et al. [139]
		↑ anandamide	Liu et al. [23]
		↑ N-acyltransferase	Pestonjamasp and Burstein [137]
		↑ phospholipase D
J774 cells	LPS	↑ anandamide	Di Marzo et al. [140]
		↑ 2-arachidonyl glycerol	Pestonjamasp and Burstein [137]
		↓ 2-arachidonyl glycerol hydrolytic activity