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Mediators of Inflammation
Volume 2016 (2016), Article ID 5953498, 6 pages
http://dx.doi.org/10.1155/2016/5953498
Research Article

Overexpression of Notch3 and pS6 Is Associated with Poor Prognosis in Human Ovarian Epithelial Cancer

1Department of Obstetrics & Gynecology, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, China
2Department of Obstetrics & Gynecology, Nanshan Hospital, Shenzhen, Guangdong 518052, China
3Department of Obstetrics & Gynecology, Xinxiang Central Hospital, Xinxiang, Henan 453600, China
4Department of Obstetrics & Gynecology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, China
5Institute of Translational Medicine, Nanchang University, Nanchang, Jiangxi 330031, China

Received 21 March 2016; Accepted 12 June 2016

Academic Editor: Shintaro Iwata

Copyright © 2016 Zhaoxia Liu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Notch3 and pS6 play important roles in tumor angiogenesis. To assess the expression of Notch3 and pS6 in Chinese ovarian epithelial cancer patients, a ten-year follow-up study was performed in ovarian epithelial cancer tissues from 120 specimens of human ovarian epithelial cancer, 30 specimens from benign ovarian tumors, and 30 samples from healthy ovaries by immunohistochemistry. The results indicate that the expression of Notch3 and pS6 was higher in ovarian epithelial cancer than in normal ovary tissues and in benign ovarian tumor tissues (). In tumor tissues, Notch3 expression and pS6 expression were negatively associated with age () but positively associated with clinical stage, pathological grading, histologic type, lymph node metastasis, and ascites ( or ). A follow-up survey of 64 patients with ovarian epithelial cancer showed that patients with high Notch3 and pS6 expression had a shorter survival time (), in which the clinical stage () and Notch3 expression () played important roles. In conclusion, Notch3 and pS6 are significantly related to ovarian epithelial cancer development and prognosis, and their combination represents a potential biomarker and therapeutic target in ovarian tumor angiogenesis.