Research Article
Diagnostic Power of Vascular Endothelial Growth Factor and Macrophage Colony-Stimulating Factor in Breast Cancer Patients Based on ROC Analysis
Table 3
Diagnostic criteria of ROC curve for tested parameters and CA 15-3.
| Tested parameters | AUC | SE | 95% C.I. (AUC) | (AUC = 0.5) |
| ROC criteria in breast cancer (total group) | VEGF | 0.729 | 0.0400 | 0.650–0.807 | <0.001 | M-CSF | 0.645 | 0.0436 | 0.559–0.730 | 0.009 | CA 15-3 | 0.698 | 0.0410 | 0.618–0.779 | <0.001 | VEGF + CA 15-3 | 0.753 | 0.0377 | 0.679–0.826 | <0.001 | M-CSF + CA 15-3 | 0.699 | 0.0409 | 0.618–0.779 | <0.001 | VEGF + M-CSF + CA 15-3 | 0.754 | 0.0377 | 0.679–0.827 | <0.001 |
| ROC criteria in breast cancer (stage I) | VEGF | 0.691 | 0.0616 | 0.570–0.811 | 0.002 | M-CSF | 0.396 | 0.0655 | 0.267–0.524 | 1.889 | CA 15-3 | 0.494 | 0.0647 | 0.367–0.621 | 1.073 | VEGF + CA 15-3 | 0.595 | 0.0680 | 0.462–0.729 | 0.161 | M-CSF + CA 15-3 | 0.455 | 0.0611 | 0.336–0.575 | 1.535 | VEGF + M-CSF + CA 15-3 | 0.596 | 0.0679 | 0.463–0.729 | 0.1561 |
| ROC criteria in breast cancer (stage II) | VEGF | 0.716 | 0.0524 | 0.613–0.818 | <0.001 | M-CSF | 0.539 | 0.0639 | 0.414–0.664 | 0.544 | CA 15-3 | 0.586 | 0.0665 | 0.456–0.716 | 0.196 | VEGF + CA 15-3 | 0.629 | 0.0637 | 0.504–0.754 | 0.043 | M-CSF + CA 15-3 | 0.568 | 0.0632 | 0.444–0.691 | 0.285 | VEGF + M-CSF + CA 15-3 | 0.629 | 0.0637 | 0.505–0.754 | 0.042 |
| ROC criteria in breast cancer (stage III) | VEGF | 0.818 | 0.0483 | 0.724–0.913 | <0.001 | M-CSF | 0.811 | 0.0484 | 0.716–0.906 | <0.001 | CA 15-3 | 0.819 | 0.0490 | 0.723–0.915 | <0.001 | VEGF + CA 15-3 | 0.878 | 0.0376 | 0.804–0.952 | <0.001 | M-CSF + CA 15-3 | 0.850 | 0.0436 | 0.765–0.936 | <0.001 | VEGF + M-CSF + CA 15-3 | 0.879 | 0.0375 | 0.805–0.952 | <0.001 |
| ROC criteria in breast cancer (stage IV) | VEGF | 0.690 | 0.0717 | 0.549–0.831 | 0.008 | M-CSF | 0.834 | 0.0461 | 0.744–0.925 | <0.001 | CA 15-3 | 0.893 | 0.0450 | 0.805–0.982 | <0.001 | VEGF + CA 15-3 | 0.908 | 0.0390 | 0.832–0.985 | <0.001 | M-CSF + CA 15-3 | 0.921 | 0.0368 | 0.848–0.993 | <0.001 | VEGF + M-CSF + CA 15-3 | 0.908 | 0.0387 | 0.832–0.984 | <0.001 |
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, statistically significantly larger AUCs compared to AUC = 0.5.
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