Research Article

Diagnostic Power of Vascular Endothelial Growth Factor and Macrophage Colony-Stimulating Factor in Breast Cancer Patients Based on ROC Analysis

Table 3

Diagnostic criteria of ROC curve for tested parameters and CA 15-3.

Tested parametersAUCSE95% C.I. (AUC) (AUC = 0.5)

ROC criteria in breast cancer (total group)
VEGF0.7290.04000.650–0.807<0.001
M-CSF0.6450.04360.559–0.7300.009
CA 15-30.6980.04100.618–0.779<0.001
VEGF + CA 15-30.7530.03770.679–0.826<0.001
M-CSF + CA 15-30.6990.04090.618–0.779<0.001
VEGF + M-CSF + CA 15-30.7540.03770.679–0.827<0.001

ROC criteria in breast cancer (stage I)
VEGF0.6910.06160.570–0.8110.002
M-CSF0.3960.06550.267–0.5241.889
CA 15-30.4940.06470.367–0.6211.073
VEGF + CA 15-30.5950.06800.462–0.7290.161
M-CSF + CA 15-30.4550.06110.336–0.5751.535
VEGF + M-CSF + CA 15-30.5960.06790.463–0.7290.1561

ROC criteria in breast cancer (stage II)
VEGF0.7160.05240.613–0.818<0.001
M-CSF0.5390.06390.414–0.6640.544
CA 15-30.5860.06650.456–0.7160.196
VEGF + CA 15-30.6290.06370.504–0.7540.043
M-CSF + CA 15-30.5680.06320.444–0.6910.285
VEGF + M-CSF + CA 15-30.6290.06370.505–0.7540.042

ROC criteria in breast cancer (stage III)
VEGF0.8180.04830.724–0.913<0.001
M-CSF0.8110.04840.716–0.906<0.001
CA 15-30.8190.04900.723–0.915<0.001
VEGF + CA 15-30.8780.03760.804–0.952<0.001
M-CSF + CA 15-30.8500.04360.765–0.936<0.001
VEGF + M-CSF + CA 15-30.8790.03750.805–0.952<0.001

ROC criteria in breast cancer (stage IV)
VEGF0.6900.07170.549–0.8310.008
M-CSF0.8340.04610.744–0.925<0.001
CA 15-30.8930.04500.805–0.982<0.001
VEGF + CA 15-30.9080.03900.832–0.985<0.001
M-CSF + CA 15-30.9210.03680.848–0.993<0.001
VEGF + M-CSF + CA 15-30.9080.03870.832–0.984<0.001

, statistically significantly larger AUCs compared to AUC = 0.5.