Imiquimod Treatment Causes Systemic Disease in Mice Resembling Generalized Pustular Psoriasis in an IL-1 and IL-36 Dependent Manner

Figure 3

Female mice develop more severe disease than male mice in response to generic imiquimod cream. Wild type male (black bars and symbols) and female (open bars and symbols) mice ( per group) were treated with 31.25 mg imiquimod cream (Perrigo) once daily for a total of 4 applications. Activity (a), nest building (b), posture (c), nose bulging (d), weight (e), and food intake (f) were evaluated as described in Figure 2 and Table 1. ND: no disease detected, score = 0. Data shown (means SD) is from one representative experiment of at least 3 independent experiments. ; (comparing female to male at individual timepoints).

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