NEMO-Binding Domain Peptide Attenuates Lipopolysaccharide-Induced Acute Lung Injury by Inhibiting the NF-κB Signaling Pathway

Figure 6

Effect of NBD on IKK, IκΒ-α, and NF-κBp65 activation in the lung tissues of mice with ALI. (a) Relative gray scale quantitation of total IκB-α, NF-κB, and β-actin phosphorylation. (b) Statistical results. IKK, IκΒ-α, and NF-κBp65 phosphorylation levels were increased by LPS administration, and these changes were inhibited by NBD pretreatment in a concentration-dependent manner. Data are expressed as the mean ± SD (n = 6). represents versus control group, < 0.05; represents versus model group, < 0.05; represents versus N-NBD group, < 0.05; represents versus NBD-2 group, < 0.05; E represents versus NBD-6 group, < 0.05.

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