Research Article
Activation of Melanocortin Receptors MC1 and MC5 Attenuates Retinal Damage in Experimental Diabetic Retinopathy
Figure 8
Expression of retinal Cd11c and Cd206 in eyes of mice with retinopathy. 16-week time point western blotting traces and relative densitometric units of binding to anti-Cd211 and Cd206 antibodies in the retina of nondiabetic mice (nondiabetic), STZ-diabetic mice with retinopathy (diabetic) after intravitreal treatment or not with MC1 receptor agonist BMS-470539; MC3-MC4 melanocortin receptor agonist MTII; MC1 receptor antagonist agouti related protein (AGRP); MC5 melanocortin receptor agonist PG-901; MC3-MC4 melanocortin receptor antagonist SHU9119; MC5 melanocortin receptor antagonist PG20N. Significant differences against nondiabetic mice are expressed as ; significant differences versus diabetic are expressed as .