Serum Cytokine Profiles in Children with Crohn’s Disease

Table 3

Serum cytokine activation in CD4/CD8 ratio subgroups of juvenile CD (median [25th–75th percentile]).

Cytokine; (pg/mL)	Controls ()	Acute patients, CD4/CD8 < 2 ()	Acute patients, CD4/CD8 > 2 ()
IL-1b	107,7 [16,4–340,8]	392,7 [131,6–807,7]	567,5 [444,5–650,0]
IL-2	2,3 [1,5–3.0]	4,4 [3,4–6,2]	3,2 [2,8–3,9]
IL-5	9,0 [3,5–11,8]	5,9 [2,7–13,6]	15,3 [4,7–22,2]
IL-6	23,5 [17,2–27,3]	54,3 [20,32–66,7]	27,8 [25,2–99,1]
IL-8	1 415,3 [997,1–2 625,4]	1760,0 [257,4–6014,1]	4161,5 [2956,0–8372,8]
IL-12	203,2 [120,3–280,0]	204,5 [144,1–426,5]	257,0 [171,8–885,3]
GM-CSF	30,4 [13,5–38,0]	33,0 [13,5–45,5]	29,5 [9,5–33,5]
IFN-γ	2,5 [1,8–3,2]	4,15 [3,2–5,2]	3,4 [2,5–4,4]
CXCL10	384,9 [265,3–435,4]	4089,5 [2835,8–4597,8]	2925,0 [2448,5–3426,0]
TNF-α	4,6 [3,3–6,2]	7,4 [5,3–9,4]	12,0 [11,5–13,0]
IL-4	8,5 [6,3–9,1]	8,9 [7,4–11,3]	8,7 [7,6–11,3]
IL-10	23,9 [17,6–32,4]	16,8 [14,3–28,0]	60,0 [32,3–94,5]

versus controls (Mann–Whitney test).
versus acute patients with CD4/CD8 ratio < 2.0 (Mann–Whitney test).