Mediators of Inflammation / 2016 / Article / Tab 2

Research Article

Extra-Articular Symptoms in Constellation with Selected Serum Cytokines and Disease Activity in Spondyloarthritis

Table 2

Comparison of serum levels of selected cytokines and markers of disease activity in spondyloarthritis patients with and without acute anterior uveitis and inflammatory bowel disease.

AAU
present
AAU
absent
IBD
present
IBD
absent

Age (years)48.90.060.1
Disease duration (years)10.0
(5.0, 19.0)
5.0
(2.0, 9.0)
0.000210.0
(5.0, 13.5)
5.0
(2.0, 10.)
0.06
HLA-B2747.10.0001100620.04
VAS pain (mm)0.00080.03
BASDAI0.00015.34.20.1
ASDAS-ESR2.7
(2.2, 3.4)
2.3
(1.8, 3.0)
0.043.1
(2.2, 4.1)
2.4
(1.8, 3.2)
0.06
DAS280.04.24<0.00010.04.24<0.0001
CRP (mg/L)10.5
(2.6, 21.1 0)
5.0
(2.0, 11.4)
0.00619.0
(7.8, 31.1)
5.5
(2.1, 12.3)
0.0009
ESR (mm/h)14.0
(5.0, 35.)
13.5
(6.0, 24.5)
0.425.514.00.05
IL-6 (pg/mL)4.5
(1.5, 10.1)
2.9
(1.5, 6.5)
0.023.3
(1.5, 6.4)
2.9
(1.5, 20.7)
0.0003
IL-18 (pg/mL)323.5
(228.7, 454.5)
271.8
(203.5, 346.2)
0.03333.8
(237.5, 285.2)
271.8
(207.3, 373.9)
0.4
IL-23(pg/mL)0.0
(0.0, 2.8)
0.0
(0.0, 1.8)
0.20.0
(0.0, 0.3)
0.0
(0.0, 2.0)
0.2
VEGF (pg/mL)406.2
(270.0, 880.0)
343.1
(223.2, 545.7)
0.05341.3
(206.3, 505.0)
347.4
(225.9, 562.2)
0.3
EGF (pg/mL)115.0
(62.0, 182.0)
104.0
(68.0, 168.0)
0.581.0
(32.0, 141.0)
104.0
(68.0, 182.0)
0.2
ET-1 (pg/mL)0.070.3

Data are presented as mean ± standard deviation, median (Q1 and Q3). AAU: acute anterior uveitis, ASDAS-ESR: Ankylosing Spondylitis Disease Activity Score, BASDAI: Bath Ankylosing Spondylitis Disease Activity Index, CRP: C-reactive protein, DAS28: Disease Activity Score 28, EGF: epidermal growth factor, ESR: erythrocyte sedimentation rate, ET-1: endothelin-1, IBD: inflammatory bowel disease, IL-6: interleukin-6, IL-18: interleukin-18, IL-23: interleukin-23, VAS pain: visual analogue scale of patient’s pain, and VEGF: vascular endothelial growth factor.

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