Mediators of Inflammation / 2016 / Article / Tab 3

Research Article

Extra-Articular Symptoms in Constellation with Selected Serum Cytokines and Disease Activity in Spondyloarthritis

Table 3

Comparison of serum levels of selected cytokines and markers of disease activity in spondyloarthritis patients with and without skin psoriasis, psoriatic onycholysis, and palmoplantar pustulosis.

Psoriasis
present
Psoriasis
absent
Psoriatic onycholysis
present
Psoriatic onycholysis
absent
PPP
present
PPP
absent

Age (years)0.0010.10.03
Disease duration (years)4.0
(2.0, 8.0)
6.0
(2.0, 11.0)
0.0044.0
(2.0, 7.0)
6.5
(2.0, 12.0)
0.0092.0
(1.0, 5.0)
6.0
(3.0, 11.0)
0.00009
HLA-B2722710.0000428700.000423680.0008
VAS pain (mm)0.0010.0060.3
BASDAI0.000070.000010.04
ASDAS-ESR1.8
(1.6, 2.1)
2.5
(1.9, 3.2)
0.0061.9
(1.6, 2.4)
2.5
(1.8, 3.2)
0.06
DAS284.25
(3.8, 4.5)
4.05
(3.0, 6.9)
0.34.24
(3.8, 4.5)
4.28
(3.7, 4.8)
0.3
CRP (mg/L)4.1
(1.6, 9.4)
6.35
(2.4, 13.3)
0.073.8
(1.6, 9.6)
6.1
(2.1, 13.5)
0.024.5
(1.1, 12.4)
5.6
(2.4, 12.0)
0.4
ESR (mm/h)13.0
(6.0, 22.0)
14.0
(6.0, 28.0)
0.213.0
(7.0, 22.0)
14.0
(6.0, 27.0)
0.221.0
(10.5, 36.0)
13.0
(6.0, 24.0)
0.004
IL-6 (pg/mL)2.5
(1.4, 6.2)
3.6
(1.7, 7.9)
0.43.4
(1.4, 6.5)
3.3
(1.6, 6.7)
0.22.4
(1.0, 6.6)
3.4
(1.5, 6.7)
0.2
IL-18 (pg/mL)290.1
(225.4, 373.9)
259.7
(205.3, 372.3)
0.3286.0
(225.4, 408.9)
264.9
(202.9, 370.0)
0.4265.0
(193.3, 377.9)
278.2
(213.6, 373.1)
0.4
IL-23(pg/mL)0.0
(0.0, 0.9)
0.0
(0.0, 2.5)
0.30.0
(0.0, 0.9)
0.0
(0.0, 2.5)
0.040.0
(0.0, 0.3)
0.0
(0.0, 2.5)
0.2
VEGF (pg/mL)343.5
(211.7, 680.0)
348.9
(229.6, 500.0)
0.5289.6
(205.7, 759.7)
347.8
(260.0, 500.0)
0.5333.1
(235.3, 390.0)
348.9.3
(225.9, 612.1)
0.1
EGF (pg/mL)130.0
(74.0, 196)
95.0
(68.0, 160.0)
0.1120.0
(74.0, 196.0)
103.0
(66.0, 164.0)
0.23104.0
(58.0, 168)
107.0
(68.0, 182.0)
0.4
ET-1 (pg/mL)0.50.50.001

Data are presented as mean ± standard deviation, median (Q1 and Q3). AAU: acute anterior uveitis, ASDAS-ESR: Ankylosing Spondylitis Disease Activity Score, BASDAI: Bath Ankylosing Spondylitis Disease Activity Index, CRP: C-reactive protein, DAS28: Disease Activity Score 28, EGF: epidermal growth factor, ESR: erythrocyte sedimentation rate, ET-1: endothelin-1, IBD: inflammatory bowel disease, IL-6: interleukin-6, IL-18: interleukin-18, IL-23: interleukin-23, PPP: palmoplantar pustulosis, VAS pain: visual analogue scale of patient’s pain, and VEGF: vascular endothelial growth factor.

Article of the Year Award: Outstanding research contributions of 2020, as selected by our Chief Editors. Read the winning articles.