Mediators of Inflammation / 2016 / Article / Tab 5

Research Article

Extra-Articular Symptoms in Constellation with Selected Serum Cytokines and Disease Activity in Spondyloarthritis

Table 5

A logistic regression model of the OR of serum levels of selected cytokines in spondyloarthritis groups of patients with different extra-articular symptoms compared to controls.

Covariates AAU IBD PsoriasisPsoriatic onycholysis PPP
OR (95% CI)OR (95% CI)OR (95% CI)OR (95% CI)OR (95% CI)

IL-6 ≥ 6.64 pg/mL6.75
(1.23–36.91)
0.025.4
(0.61–47.76)
0.124.29
(0.81–22.80)
0.084.35
(0.87–21.64)
0.075.06
(0.91–28.15)
0.06
IL-18 ≥ 227.45 pg/mL8.17
(2.46–27.03)
0.00067.0
(1.17–41.53)
0.039.0
(2.87–28.16)
0.00026.82
(2.50–18.59)
0.00023.69
(1.27–10.71)
0.01
IL-23 ≥ 2.5 pg/mL23.9
(1.28–444.01)
0.0313.6
(0.49–373.39)
0.1215.6
(0.83–291.96)
0.0611.49
(0.63–209.44)
0.097.55
(0.34–166.21)
0.19
ET-1 ≤ 1,081 pg/mL9.45
(2.56–34.79)
0.00070.23
(0.04–1.11)
0.065.77
(1.65–20.15)
0.0064.93
(1.50–16.20)
0.0081.89
(0.49–7.29)
0.35
VEGF ≥ 420.9 pg/mL2.5
(0.60–10.26)
0.200.83
(0.07–9.68)
0.81.18
(0.34–4.07)
0.71.71
(0.51–5.82)
0.380.5
(0.08–2.99)
0.4
EGF ≥ 172.0 pg/mL1.28
(0.27–5.93)
0.70.33
(0.01–7.23)
0.41.34
(0.36–4.94)
0.61.34
(0.36–4.94)
0.60.96
(0.18–4.92)
0.9

AAU: acute anterior uveitis, EGF: epidermal growth factor, ET-1: endothelin-1, IBD: inflammatory bowel disease, IL-6: interleukin-6, IL-18: interleukin-18, IL-23: interleukin-23, OR: odds ratio, PPP: palmoplantar pustulosis, and VEGF: vascular endothelial growth factor.

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