Effect of Toll-Like Receptor 4 on Synovial Injury of Temporomandibular Joint in Rats Caused by Occlusal Interference

<div>The expression of TLR4 in the synovial membranes. (a) Immunohistochemical staining for TLR4 in the membranes of the control group. (b) Immunohistochemical staining for TLR4 in the membranes of occlusal interference group. (c) Immunohistochemical staining for TLR4 in the membranes of TAK-242 group. (d) The mean optical density of each group. (e) The relative mRNA expression of TLR4 of each group. As the results shown, in comparison with the control group, the expression of TLR4 was significantly increased in the occlusal interference group at both protein and mRNA levels. However, this effect could be inhibited significantly after treatment with the TAK-242. 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Mediators of Inflammation

fig2

Figure 2

Figure 2: Effect of Toll-Like Receptor 4 on Synovial Injury of Temporomandibular Joint in Rats Caused by Occlusal Interference 