Effect of Toll-Like Receptor 4 on Synovial Injury of Temporomandibular Joint in Rats Caused by Occlusal Interference

Figure 3

Effect of TLR4 on the expression of IL-1β in the synovial membranes. (a) Immunohistochemical staining for IL-1β in the membranes of the control group. (b) Immunohistochemical staining for IL-1β in the membranes of occlusal interference group. (c) Immunohistochemical staining for IL-1β in the membranes of TAK-242 group. (d) The mean optical density of each group. (e) The relative mRNA expression of IL-1β of each group. As the results shown, in comparison with the control group, the expression of IL-1β was significantly increased in the occlusal interference group at both protein and mRNA levels. However, this effect could be inhibited significantly after treatment with the TAK-242. Data shows all the values from independent samples of , versus control group and versus occlusal interference group.

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