Research Article
Targeting Endothelial Adhesion Molecule Transcription for Treatment of Inflammatory Disease: A Proof-of-Concept Study
Table 2
Transcription factors with putative binding sites within the regulatory region of intercellular adhesion molecule 1 (ICAM-1) that increase in human retinal endothelial cells treated with tumor necrosis factor-alpha (TNF-α). For the purposes of this analysis, the ICAM-1 regulatory region was defined as 5000 bp of sequence immediately upstream of the ICAM-1 gene transcription start site and the first 2 introns. The ICAM-1 gene sequence was interrogated in the JASPAR database [21].
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ETS1 = E26 transformation-specific 1; EGR1 = early growth response 1; IRF1 = interferon regulatory factor 1; NF-κB1 = nuclear factor κ-light-chain-enhancer of activated B-cells 1; TGIF1 = TGFB-induced factor homeobox 1. |