Elevated Admission Base Deficit Is Associated with a Complex Dynamic Network of Systemic Inflammation Which Drives Clinical Trajectories in Blunt Trauma Patients

Table 3

Summary of the area under the curve (AUC) analysis from the time of injury up to day 7 for statistically significantly different inflammatory mediators (by two-way ANOVA) between the BD < 4 and the BD 4 subgroups.

Inflammation biomarkers (0 h–day 7 after injury)	BD ≥ 4 (pg.h/L)	BD < 4 (pg.h/L)	Fold change	value
IL-1RA	7409.3	3731.0	2.0	<0.001
IL-5	276.1	150.4	1.8	0.005
IL-7	880.2	479.5	1.8	0.001
sIL-2Rα	4026.7	2356.0	1.7	<0.001
IL-6	1648.9	1022.5	1.6	0.013
MCP-1/CCL2	7254.3	4747.9	1.5	<0.001
IFN-γ	485.0	332.5	1.5	0.002
IL-13	223.5	159.9	1.4	0.002
IL-4	466.3	342.1	1.4	0.002
IL-8/CCL8	546.7	401.6	1.4	0.045
IFN-α	575.3	430.6	1.3	<0.001
IL-2	100.8	79.6	1.3	0.037
MIP-1β/CCL4	993.0	789.2	1.3	0.029
TNF-α	115.9	94.2	1.2	0.003