Novel Role of Endogenous Catalase in Macrophage Polarization in Adipose Tissue
Table 2
Metabolic characteristics of experimental mice.
Parameters
ND
HFD
WT
CKO
WT
CKO
Body weight (g)
32.2 ± 0.7
31.5 ± 0.9
45.1 ± 1.5
47.8 ± 2.2
Epididymal fat mass (g)
0.38 ± 0.06
0.41 ± 0.10
1.94 ± 0.13
1.66 ± 0.13
Plasma free fatty acids (µM)
0.47 ± 0.02
0.6 ± 0.04
0.52 ± 0.07
0.77 ± 0.13
Plasma triglycerides (mM)
0.72 ± 0.04
0.93 ± 0.07
0.97 ± 0.07
1.04 ± 0.11
Plasma LDL/VLDL (mg/dL)
21.5 ± 4.0
30.7 ± 1.5
70.9 ± 5.0
62.2 ± 8.6
Plasma HDL (mg/dL)
89.7 ± 6.0
95.7 ± 4.9
90.7 ± 8.0
101.5 ± 5.5
Fed plasma insulin (ng/mL)
1.54 ± 0.38
2.22 ± 0.51
6.16 ± 1.11
10.08 ± 1.83
Fasting plasma insulin (ng/mL)
0.21 ± 0.02
0.24 ± 0.06
0.50 ± 0.09
1.20 ± 0.29
HOMA-IR
2.44 ± 0.34
2.22 ± 0.69
7.39 ± 1.24
14.17 ± 4.04
WT and CKO C57BL/6 J mice were divided into four groups: WT ND, CKO ND, WT HFD, and CKO HFD. They were fed either ND (18% fat-derived calories) or HFD (60.3% fat-derived calories) for 21 weeks. Blood was collected from orbital sinus of all mice for measurement of plasma insulin at 21 weeks after HFD and a day before sacrificing. Data were shown as mean ± SE of 6–8 mice. versus WT ND, versus CKO ND, and versus WT HFD.
